The Canadian Healthy Infant Longitudinal Development (CHILD) study: Examining developmental origins of allergy and asthma

CHILD study investigators

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalThorax
Volume70
Issue number10
DOIs
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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