The carcinogen benzo(e)pyrene is metabolized by DM15 cells without an uncoupling effect on their gap junctions

Irina V. Budunova*, Leonid A. Mittleman, Radjab D. Safaev, Serge Yu Fuchs, Gennady A. Belitsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Benzo(e)pyrene (B(e)P) promotes carcinogenesis in the skin. Unlike some other promoters however, B(e)P does notproduce an uncoupling effect on gap junction permeability in DM15 transformedfibroblasts. This study demonstrates thatDM15 cells exhibit a relatively high level of B(e)P metabolism. Moreover, although pretreatment of DM15 cells with benz(a)anthracene results in an 8-fold increase of arylhydrocarbon hydroxylase activity and a 2-fold increase in the rate ofB(e)P metabolism, it did not enable B(e)P to affectLucifer Yellow transfer between DM15 cells. We conclude that neitherB(e)P nor its metabolites are capable of uncoupling gap junction permeability in DM15 cells.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalCell Biology and Toxicology
Volume9
Issue number2
DOIs
StatePublished - Jun 1 1993

Keywords

  • benzo(e)pyrene dye transfer
  • intercellular communication

ASJC Scopus subject areas

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

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