The cardiac atlas project: Preliminary description of heart shape in patients with myocardial infarction

Pau Medrano-Gracia*, Brett R. Cowan, J. Paul Finn, Carissa G. Fonseca, Alan H. Kadish, Dan C. Lee, Wenchao Tao, Alistair A. Young

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

The Cardiac Atlas Project seeks to establish a standardized database of cardiovascular imaging examinations, together with derived analyses, for the purposes of statistical characterization of global and regional heart function abnormalities. We present preliminary results from a subset of cases contributed from the Defibrillators to Reduce Risk by Magnetic Resonance Imaging Evaluation (DETERMINE) study of patients with myocardial infarction. Finite element models were fitted to the epicardial and endocardial surfaces throughout the cardiac cycle in 200 patients using a standardized procedure. The control points of the shape model were used in a principal component analysis of shape and motion. The modes were associated with well-known clinical indices of adverse remodeling in heart disease, including heart size, sphericity and mitral valve geometry. These results therefore show promise for the clinical application of a statistical analysis of shape and motion in patients with myocardial infarction.

Original languageEnglish (US)
Title of host publicationStatistical Atlases and Computational Models of the Heart - First Int. Workshop, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conj. with MICCAI 2010, Proc.
Pages46-53
Number of pages8
DOIs
StatePublished - Nov 8 2010
Event1st International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conjunction with MICCAI 2010 - Beijing, China
Duration: Sep 20 2010Sep 20 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6364 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conjunction with MICCAI 2010
CountryChina
CityBeijing
Period9/20/109/20/10

Keywords

  • Cardiac Magnetic Resonance Imaging (MRI)
  • Finite Element Modeling
  • Principal Component Analysis
  • Statistical Shape Model

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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    Medrano-Gracia, P., Cowan, B. R., Finn, J. P., Fonseca, C. G., Kadish, A. H., Lee, D. C., Tao, W., & Young, A. A. (2010). The cardiac atlas project: Preliminary description of heart shape in patients with myocardial infarction. In Statistical Atlases and Computational Models of the Heart - First Int. Workshop, STACOM 2010 and Cardiac Electrophysiological Simulation Challenge, CESC 2010 - Held in Conj. with MICCAI 2010, Proc. (pp. 46-53). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6364 LNCS). https://doi.org/10.1007/978-3-642-15835-3_5