The cause and pathogenesis of the eosinophilia-myalgia syndrome

John Varga; Jouni Uitto; Sergio A. Jimenez

doi:10.7326/0003-4819-116-2-140

The cause and pathogenesis of the eosinophilia-myalgia syndrome

John Varga^*, Jouni Uitto, Sergio A. Jimenez

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Objective: To review recent advances in the understanding of the cause and pathogenesis of the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Data Sources: Studies published from 1989 to 1991 were identified using a MEDLINE literature search. Additional references were selected from the bibliographies of identified articles. Data Synthesis: The eosinophilia-myalgia syndrome was epidemiologically associated with ingestion of L-tryptophan-containing preparations. Analysis of case-associated lots of L-tryptophan has revealed several chemical impurities. One of these, labeled "peak E,

Original language	English (US)
Pages (from-to)	140-147
Number of pages	8
Journal	Annals of internal medicine
Volume	116
Issue number	2
DOIs	https://doi.org/10.7326/0003-4819-116-2-140
State	Published - Jan 15 1992

ASJC Scopus subject areas

Internal Medicine

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10.7326/0003-4819-116-2-140

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title = "The cause and pathogenesis of the eosinophilia-myalgia syndrome",

abstract = "Objective: To review recent advances in the understanding of the cause and pathogenesis of the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Data Sources: Studies published from 1989 to 1991 were identified using a MEDLINE literature search. Additional references were selected from the bibliographies of identified articles. Data Synthesis: The eosinophilia-myalgia syndrome was epidemiologically associated with ingestion of L-tryptophan-containing preparations. Analysis of case-associated lots of L-tryptophan has revealed several chemical impurities. One of these, labeled {"}peak E,",

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AU - Uitto, Jouni

AU - Jimenez, Sergio A.

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Y1 - 1992/1/15

N2 - Objective: To review recent advances in the understanding of the cause and pathogenesis of the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Data Sources: Studies published from 1989 to 1991 were identified using a MEDLINE literature search. Additional references were selected from the bibliographies of identified articles. Data Synthesis: The eosinophilia-myalgia syndrome was epidemiologically associated with ingestion of L-tryptophan-containing preparations. Analysis of case-associated lots of L-tryptophan has revealed several chemical impurities. One of these, labeled "peak E,

AB - Objective: To review recent advances in the understanding of the cause and pathogenesis of the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Data Sources: Studies published from 1989 to 1991 were identified using a MEDLINE literature search. Additional references were selected from the bibliographies of identified articles. Data Synthesis: The eosinophilia-myalgia syndrome was epidemiologically associated with ingestion of L-tryptophan-containing preparations. Analysis of case-associated lots of L-tryptophan has revealed several chemical impurities. One of these, labeled "peak E,

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The cause and pathogenesis of the eosinophilia-myalgia syndrome

Abstract

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