The cause and pathogenesis of the eosinophilia-myalgia syndrome

John Varga*, Jouni Uitto, Sergio A. Jimenez

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Objective: To review recent advances in the understanding of the cause and pathogenesis of the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. Data Sources: Studies published from 1989 to 1991 were identified using a MEDLINE literature search. Additional references were selected from the bibliographies of identified articles. Data Synthesis: The eosinophilia-myalgia syndrome was epidemiologically associated with ingestion of L-tryptophan-containing preparations. Analysis of case-associated lots of L-tryptophan has revealed several chemical impurities. One of these, labeled "peak E,

Original languageEnglish (US)
Pages (from-to)140-147
Number of pages8
JournalAnnals of internal medicine
Volume116
Issue number2
DOIs
StatePublished - Jan 15 1992

ASJC Scopus subject areas

  • Internal Medicine

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