The CD95(APO-1/Fas) DISC and beyond

M. E. Peter*, P. H. Krammer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

864 Scopus citations

Abstract

CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tall. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.

Original languageEnglish (US)
Pages (from-to)26-35
Number of pages10
JournalCell Death and Differentiation
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Apoptosis
  • DISC
  • TNF

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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