The CD95(APO-1/Fas) DISC and beyond

M. E. Peter; P. H. Krammer

doi:10.1038/sj.cdd.4401186

The CD95(APO-1/Fas) DISC and beyond

M. E. Peter^*, P. H. Krammer

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

900 Scopus citations

Abstract

CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tall. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.

Original language	English (US)
Pages (from-to)	26-35
Number of pages	10
Journal	Cell Death and Differentiation
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/sj.cdd.4401186
State	Published - Jan 1 2003

Keywords

Apoptosis
DISC
TNF

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cdd.4401186

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abstract = "CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tall. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.",

keywords = "Apoptosis, DISC, TNF",

author = "Peter, {M. E.} and Krammer, {P. H.}",

note = "Funding Information: We thank A Kr{\"u}ger and B Barnhart for critically reading the manuscript. This work was supported by grants from the Deutsche Forschungsge-meinschaft, the European Community, the Deutsche Krebshilfe, the Sander Stiftung, the Tumor Center Heidelberg/Mannheim, the BMBF, the German–Israeli Cooperation in Cancer Research and NIH Grant GM61712-01.",

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AB - CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tall. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.

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The CD95(APO-1/Fas) DISC and beyond

Abstract

Keywords

ASJC Scopus subject areas

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