The central role of EED in the orchestration of polycomb group complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan*

*Corresponding author for this work

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.

Original languageEnglish (US)
Article number3127
JournalNature communications
Volume5
DOIs
StatePublished - Jan 24 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Cao, Q., Wang, X., Zhao, M., Yang, R., Malik, R., Qiao, Y., Poliakov, A., Yocum, A. K., Li, Y., Chen, W., Cao, X., Jiang, X., Dahiya, A., Harris, C., Feng, F. Y., Kalantry, S., Qin, Z. S., Dhanasekaran, S. M., & Chinnaiyan, A. M. (2014). The central role of EED in the orchestration of polycomb group complexes. Nature communications, 5, [3127]. https://doi.org/10.1038/ncomms4127