The central (spinal) canal in congenital murine hydrocephalus: morphological and physiological aspects.

K. Kuwamura*, D. G. McLone, A. J. Raimondi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Obstruction of cerebrospinal fluid pathways produces changes in the parenchyma of the brain and spinal cord. A murine model of hydrocephalus (hy-3) used to study changes in the central canal of the spinal cord and these changes are correlated with events occurring in the intracranial compartment. The central canal is enlarged and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as the intracranial ventricular system is expanding. Plugging of the obex results in collapse of the central canal. Ferritin tracer studies demonstrate transependymal flow of cerebrospinal fluid throughout the central canal.

Original languageEnglish (US)
Pages (from-to)216-234
Number of pages19
JournalChild's Brain
Volume4
Issue number4
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)
  • Clinical Neurology

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