The central (spinal) canal in congenital murine hydrocephalus: morphological and physiological aspects.

K. Kuwamura; D. G. McLone; A. J. Raimondi

doi:10.1159/000119779

The central (spinal) canal in congenital murine hydrocephalus: morphological and physiological aspects.

K. Kuwamura^*, D. G. McLone, A. J. Raimondi

^*Corresponding author for this work

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Abstract

Obstruction of cerebrospinal fluid pathways produces changes in the parenchyma of the brain and spinal cord. A murine model of hydrocephalus (hy-3) used to study changes in the central canal of the spinal cord and these changes are correlated with events occurring in the intracranial compartment. The central canal is enlarged and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as the intracranial ventricular system is expanding. Plugging of the obex results in collapse of the central canal. Ferritin tracer studies demonstrate transependymal flow of cerebrospinal fluid throughout the central canal.

Original language	English (US)
Pages (from-to)	216-234
Number of pages	19
Journal	Child's Brain
Volume	4
Issue number	4
DOIs	https://doi.org/10.1159/000119779
State	Published - 1978

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neuroscience(all)
Clinical Neurology

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abstract = "Obstruction of cerebrospinal fluid pathways produces changes in the parenchyma of the brain and spinal cord. A murine model of hydrocephalus (hy-3) used to study changes in the central canal of the spinal cord and these changes are correlated with events occurring in the intracranial compartment. The central canal is enlarged and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as the intracranial ventricular system is expanding. Plugging of the obex results in collapse of the central canal. Ferritin tracer studies demonstrate transependymal flow of cerebrospinal fluid throughout the central canal.",

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AU - Raimondi, A. J.

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AB - Obstruction of cerebrospinal fluid pathways produces changes in the parenchyma of the brain and spinal cord. A murine model of hydrocephalus (hy-3) used to study changes in the central canal of the spinal cord and these changes are correlated with events occurring in the intracranial compartment. The central canal is enlarged and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as the intracranial ventricular system is expanding. Plugging of the obex results in collapse of the central canal. Ferritin tracer studies demonstrate transependymal flow of cerebrospinal fluid throughout the central canal.

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The central (spinal) canal in congenital murine hydrocephalus: morphological and physiological aspects.

Abstract

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