The challenges and innovations for therapy in children with epilepsy

Jo M. Wilmshurst*, Anne T. Berg, Lieven Lagae, Charles R. Newton, J. Helen Cross

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Major advances have been made in the diagnosis, evaluation and management of children with epilepsy over the past 15 years. There has been a marked increase in genetic diagnoses of a number of key childhood-onset epilepsy syndromes, such as Dravet syndrome, which has been linked to mutations in the SCN1A gene. The reorganization and reclassification of epilepsies, devised by the International League Against Epilepsy, has stimulated specialists to reassess their diagnostic practices; however, many studies have not addressed the global issues in treating children with epilepsy - specifically, the challenges of diagnosis through to optimal, and appropriate, therapeutic management. Also, Class I evidence-based data that are needed as a foundation for the development of treatment guidelines worldwide are lacking. Epilepsy is common, and the impact of this disease crosses age ranges and should be managed at all levels of care from community to quaternary care. In this Review, existing data and new therapeutic management approaches are discussed with the aim of highlighting the incidence of standard practices that may not be based on clinical evidence.

Original languageEnglish (US)
Pages (from-to)249-260
Number of pages12
JournalNature Reviews Neurology
Volume10
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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