The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus; James M. Gold; Deanna M. Barch; Trina M. Walker; Charlotte A. Chun; Robert W. Buchanan; John G. Csernansky; Donald C. Goff; Michael F. Green; L. Fredrik Jarskog; Daniel C. Javitt; David Kimhy; Jeffrey A. Lieberman; Joseph P. McEvoy; Raquelle I. Mesholam-Gately; Larry J. Seidman; M. Patricia Ball; Robert S. Kern; Robert P. McMahon; James Robinson; Stephen R. Marder; Richard S.E. Keefe

doi:10.1016/j.scog.2019.100161

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus^*, James M. Gold, Deanna M. Barch, Trina M. Walker, Charlotte A. Chun, Robert W. Buchanan, John G. Csernansky, Donald C. Goff, Michael F. Green, L. Fredrik Jarskog, Daniel C. Javitt, David Kimhy, Jeffrey A. Lieberman, Joseph P. McEvoy, Raquelle I. Mesholam-Gately, Larry J. Seidman, M. Patricia Ball, Robert S. Kern, Robert P. McMahon, James RobinsonStephen R. Marder, Richard S.E. Keefe

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article

Abstract

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

Original language	English (US)
Article number	100161
Journal	Schizophrenia Research: Cognition
Volume	19
DOIs	https://doi.org/10.1016/j.scog.2019.100161
State	Published - Mar 2020

ASJC Scopus subject areas

Cognitive Neuroscience
Psychiatry and Mental health

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Kraus, M. S., Gold, J. M., Barch, D. M., Walker, T. M., Chun, C. A., Buchanan, R. W., Csernansky, J. G., Goff, D. C., Green, M. F., Jarskog, L. F., Javitt, D. C., Kimhy, D., Lieberman, J. A., McEvoy, J. P., Mesholam-Gately, R. I., Seidman, L. J., Ball, M. P., Kern, R. S., McMahon, R. P., ... Keefe, R. S. E. (2020). The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophrenia Research: Cognition, 19, [100161]. https://doi.org/10.1016/j.scog.2019.100161

Kraus, Michael S. ; Gold, James M. ; Barch, Deanna M. ; Walker, Trina M. ; Chun, Charlotte A. ; Buchanan, Robert W. ; Csernansky, John G. ; Goff, Donald C. ; Green, Michael F. ; Jarskog, L. Fredrik ; Javitt, Daniel C. ; Kimhy, David ; Lieberman, Jeffrey A. ; McEvoy, Joseph P. ; Mesholam-Gately, Raquelle I. ; Seidman, Larry J. ; Ball, M. Patricia ; Kern, Robert S. ; McMahon, Robert P. ; Robinson, James ; Marder, Stephen R. ; Keefe, Richard S.E. / The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial : Psychometric properties and correlations with standard measures. In: Schizophrenia Research: Cognition. 2020 ; Vol. 19.

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title = "The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures",

abstract = "In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.",

author = "Kraus, {Michael S.} and Gold, {James M.} and Barch, {Deanna M.} and Walker, {Trina M.} and Chun, {Charlotte A.} and Buchanan, {Robert W.} and Csernansky, {John G.} and Goff, {Donald C.} and Green, {Michael F.} and Jarskog, {L. Fredrik} and Javitt, {Daniel C.} and David Kimhy and Lieberman, {Jeffrey A.} and McEvoy, {Joseph P.} and Mesholam-Gately, {Raquelle I.} and Seidman, {Larry J.} and Ball, {M. Patricia} and Kern, {Robert S.} and McMahon, {Robert P.} and James Robinson and Marder, {Stephen R.} and Keefe, {Richard S.E.}",

year = "2020",

month = mar,

doi = "10.1016/j.scog.2019.100161",

language = "English (US)",

volume = "19",

journal = "Schizophrenia Research: Cognition",

issn = "2215-0013",

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Kraus, MS, Gold, JM, Barch, DM, Walker, TM, Chun, CA, Buchanan, RW, Csernansky, JG, Goff, DC, Green, MF, Jarskog, LF, Javitt, DC, Kimhy, D, Lieberman, JA, McEvoy, JP, Mesholam-Gately, RI, Seidman, LJ, Ball, MP, Kern, RS, McMahon, RP, Robinson, J, Marder, SR & Keefe, RSE 2020, 'The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures', Schizophrenia Research: Cognition, vol. 19, 100161. https://doi.org/10.1016/j.scog.2019.100161

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial : Psychometric properties and correlations with standard measures. / Kraus, Michael S.; Gold, James M.; Barch, Deanna M.; Walker, Trina M.; Chun, Charlotte A.; Buchanan, Robert W.; Csernansky, John G.; Goff, Donald C.; Green, Michael F.; Jarskog, L. Fredrik; Javitt, Daniel C.; Kimhy, David; Lieberman, Jeffrey A.; McEvoy, Joseph P.; Mesholam-Gately, Raquelle I.; Seidman, Larry J.; Ball, M. Patricia; Kern, Robert S.; McMahon, Robert P.; Robinson, James; Marder, Stephen R.; Keefe, Richard S.E.

In: Schizophrenia Research: Cognition, Vol. 19, 100161, 03.2020.

Research output: Contribution to journal › Article

TY - JOUR

T1 - The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial

T2 - Psychometric properties and correlations with standard measures

AU - Kraus, Michael S.

AU - Gold, James M.

AU - Barch, Deanna M.

AU - Walker, Trina M.

AU - Chun, Charlotte A.

AU - Buchanan, Robert W.

AU - Csernansky, John G.

AU - Goff, Donald C.

AU - Green, Michael F.

AU - Jarskog, L. Fredrik

AU - Javitt, Daniel C.

AU - Kimhy, David

AU - Lieberman, Jeffrey A.

AU - McEvoy, Joseph P.

AU - Mesholam-Gately, Raquelle I.

AU - Seidman, Larry J.

AU - Ball, M. Patricia

AU - Kern, Robert S.

AU - McMahon, Robert P.

AU - Robinson, James

AU - Marder, Stephen R.

AU - Keefe, Richard S.E.

PY - 2020/3

Y1 - 2020/3

N2 - In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

AB - In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

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