The chemical neuroanatomy of breathing

George F. Alheid; Donald R. McCrimmon

doi:10.1016/j.resp.2008.07.014

The chemical neuroanatomy of breathing

George F. Alheid^*, Donald R. McCrimmon

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

163 Scopus citations

Abstract

The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.

Original language	English (US)
Pages (from-to)	3-11
Number of pages	9
Journal	Respiratory Physiology and Neurobiology
Volume	164
Issue number	1-2
DOIs	https://doi.org/10.1016/j.resp.2008.07.014
State	Published - Dec 10 2008

Funding

This work was supported by NIH grants, HL 72415, HL 73474, HL 80208.

Keywords

Bötzinger
Kölliker-Fuse nucleus
Parabrachial nucleus
Parafacial respiratory group
PreBötzinger
Retrotrapezoid nucleus
Ventral respiratory column
Ventral respiratory group

ASJC Scopus subject areas

Physiology
General Neuroscience
Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.resp.2008.07.014

Cite this

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title = "The chemical neuroanatomy of breathing",

abstract = "The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into {"}compartments{"} within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.",

keywords = "B{\"o}tzinger, K{\"o}lliker-Fuse nucleus, Parabrachial nucleus, Parafacial respiratory group, PreB{\"o}tzinger, Retrotrapezoid nucleus, Ventral respiratory column, Ventral respiratory group",

author = "Alheid, {George F.} and McCrimmon, {Donald R.}",

note = "Funding Information: This work was supported by NIH grants, HL 72415, HL 73474, HL 80208. ",

year = "2008",

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doi = "10.1016/j.resp.2008.07.014",

language = "English (US)",

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T1 - The chemical neuroanatomy of breathing

AU - Alheid, George F.

AU - McCrimmon, Donald R.

N1 - Funding Information: This work was supported by NIH grants, HL 72415, HL 73474, HL 80208.

PY - 2008/12/10

Y1 - 2008/12/10

N2 - The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.

AB - The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.

KW - Bötzinger

KW - Kölliker-Fuse nucleus

KW - Parabrachial nucleus

KW - Parafacial respiratory group

KW - PreBötzinger

KW - Retrotrapezoid nucleus

KW - Ventral respiratory column

KW - Ventral respiratory group

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M3 - Review article

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JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

IS - 1-2

ER -

The chemical neuroanatomy of breathing

Abstract

Funding

Keywords

ASJC Scopus subject areas

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