The chicken chorioallantoic membrane model in biology, medicine and bioengineering

Patrycja Nowak-Sliwinska*, Tatiana Segura, M. Luisa Iruela-Arispe

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

167 Scopus citations

Abstract

The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has been shared by specialists working in bioengineering, development, morphology, biochemistry, transplant biology, cancer research and drug development. The tissue composition and accessibility of the CAM for experimental manipulation, makes it an attractive preclinical in vivo model for drug screening and/or for studies of vascular growth. In this article we provide a detailed review of the use of the CAM to study vascular biology and response of blood vessels to a variety of agonists. We also present distinct cultivation protocols discussing their advantages and limitations and provide a summarized update on the use of the CAM in vascular imaging, drug delivery, pharmacokinetics and toxicology.

Original languageEnglish (US)
Pages (from-to)779-804
Number of pages26
JournalAngiogenesis
Volume17
Issue number4
DOIs
StatePublished - Oct 1 2014

Keywords

  • Angiogenesis
  • Anti-vascular therapies
  • Bioengineering
  • Chicken chorioallantoic membrane
  • Lymphangiogenesis
  • Organ transplantation
  • Physical forces
  • Tumor vasculature

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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