TY - JOUR
T1 - The chicken chorioallantoic membrane model in biology, medicine and bioengineering
AU - Nowak-Sliwinska, Patrycja
AU - Segura, Tatiana
AU - Iruela-Arispe, M. Luisa
N1 - Publisher Copyright:
© 2014 Springer Science+Business Media Dordrecht.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has been shared by specialists working in bioengineering, development, morphology, biochemistry, transplant biology, cancer research and drug development. The tissue composition and accessibility of the CAM for experimental manipulation, makes it an attractive preclinical in vivo model for drug screening and/or for studies of vascular growth. In this article we provide a detailed review of the use of the CAM to study vascular biology and response of blood vessels to a variety of agonists. We also present distinct cultivation protocols discussing their advantages and limitations and provide a summarized update on the use of the CAM in vascular imaging, drug delivery, pharmacokinetics and toxicology.
AB - The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has been shared by specialists working in bioengineering, development, morphology, biochemistry, transplant biology, cancer research and drug development. The tissue composition and accessibility of the CAM for experimental manipulation, makes it an attractive preclinical in vivo model for drug screening and/or for studies of vascular growth. In this article we provide a detailed review of the use of the CAM to study vascular biology and response of blood vessels to a variety of agonists. We also present distinct cultivation protocols discussing their advantages and limitations and provide a summarized update on the use of the CAM in vascular imaging, drug delivery, pharmacokinetics and toxicology.
KW - Angiogenesis
KW - Anti-vascular therapies
KW - Bioengineering
KW - Chicken chorioallantoic membrane
KW - Lymphangiogenesis
KW - Organ transplantation
KW - Physical forces
KW - Tumor vasculature
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U2 - 10.1007/s10456-014-9440-7
DO - 10.1007/s10456-014-9440-7
M3 - Review article
C2 - 25138280
AN - SCOPUS:84907593135
SN - 0969-6970
VL - 17
SP - 779
EP - 804
JO - Angiogenesis
JF - Angiogenesis
IS - 4
ER -