@article{dad10278440c4d13ae4dee7ef11208da,
title = "The childhood asthma management program (CAMP): Design, rationale, and methods",
abstract = "The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.",
keywords = "Albuterol, Allergens, Anti-inflammatory agents, Atopy, Bronchial provocation test, Bronchodilator agents, Budesonide, Childhood asthma, Clinical trials, Environmental exposure, Glucocorticoids, Growth, Inhaled bronchodilator, Nedocromil, Psychological test, Spirometry",
author = "{Childhood Asthma Management Program Research Group} and Shapiro, {Gail G.} and DuHamel, {Thomas R.} and Wighton, {Timothy G.} and Tamara Chinn and Bierman, {C. Warren} and Furukawa, {Clifton T.} and Altman, {Leonard C.} and Virant, {Frank S.} and Williams, {Paul V.} and Minotti, {Dominick A.} and Kennedy, {Michael S.} and Becker, {Jonathan W.} and Chris Reagan and Heather Eliassen and Dan Crawford and Babi Hammond and Grace Strodtbeck and Marian Sharpe and Scott Weiss and Dirk Greineder and Walter Torda and Martha Tata and Peter Barrant and Anthony DeFilippo and Mary Grace and Stephanie Haynes and Margaret Higham and Susan Kelleher and Jay Koslof and Nancy Madden and Dana Mandel and Agnes Martinez and Jean McAuliffe and Paola Pacella and Paula Parks and Anne Plunkett and Kay Seligsohn and June Traylor and {Van Horn}, Melissa and Janice Ware and Carolyn Wells and Ann Whitman and Joe Reisman and Ian MacLusky and Henry Levison and Anita Hall and Yola Benedet and Jennifer Chay and Michelle Collinson and Sai Nimmagadda",
note = "Funding Information: The Childhood Asthma Management Program is supported by Contracts NO1-HR-16044, 16045, 16046, 16047, 16048, 16049, 16050, 16051, and 16052 with the National Heart, Lung, and Blood Institute. Appendix The members of the CAMP Research Group as of February 1998 are as follows. Publisher Copyright: {\textcopyright} Elsevier Science Inc. 1999.",
year = "1999",
month = feb,
doi = "10.1016/S0197-2456(98)00044-0",
language = "English (US)",
volume = "20",
pages = "91--120",
journal = "Controlled Clinical Trials",
issn = "0197-2456",
publisher = "Elsevier BV",
number = "1",
}