The cholinergic system in the basal forebrain of the Atlantic white-sided dolphin (Lagenorhynchus acutus)

George Andrew Reid, Changiz Geula, Sultan Darvesh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The basal forebrain (BFB) cholinergic neurotransmitter system is important in a number of brain functions including attention, memory, and the sleep-wake cycle. The size of this region has been linked to the increase in encephalization of the brain in a number of species. Cetaceans, particularly those belonging to the family Delphinidae, have a relatively large brain compared to its body size and it is expected that the cholinergic BFB in the dolphin would be a prominent feature. However, this has not yet been explored in detail. This study examines and maps the neuroanatomy and cholinergic chemoarchitecture of the BFB in the Atlantic white-sided dolphin (Lagenorhynchus acutus). As in some other mammals, the BFB in this species is a prominent structure along the medioventral surface of the brain. The parcellation and distribution of cholinergic neural elements of the dolphin BFB was comparable to that observed in other mammals in that it has a medial septal nucleus, a nucleus of the vertical limb of the diagonal band of Broca, a nucleus of the horizontal limb of the diagonal band of Broca, and a nucleus basalis of Meynert. The observed BFB cholinergic system of this dolphin is consistent with evolutionarily conserved and important functions for survival.

Original languageEnglish (US)
Pages (from-to)1910-1926
Number of pages17
JournalJournal of Comparative Neurology
Volume526
Issue number12
DOIs
StatePublished - Aug 15 2018

Keywords

  • RRID# AB_2079751
  • acetylcholinesterase
  • bed nucleus of stria terminalis
  • bed nucleus of the anterior commissure
  • butyrylcholinesterase
  • central nervous system
  • cetacean
  • cetartiodactyls
  • choline acetyltransferase
  • islands of Calleja
  • medial septal nucleus
  • nucleus basalis of Meynert
  • nucleus of the horizontal limb of the diagonal band of Broca
  • nucleus of the vertical limb of the diagonal band of Broca
  • olfactory tubercle

ASJC Scopus subject areas

  • Neuroscience(all)

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