TY - JOUR
T1 - The Chromatin Signaling Pathway
T2 - Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes
AU - Smith, Edwin
AU - Shilatifard, Ali
N1 - Funding Information:
We thank Laura Shilatifard for editorial assistance. The studies in the Shilatifard laboratory are supported in part by grants from the National Institute of Health: R01GM069905, R01CA150265, and R01CA89455.
PY - 2010/12/10
Y1 - 2010/12/10
N2 - Posttranslational modifications of histones are coupled in the regulation of the cellular processes involving chromatin, such as transcription, replication, repair, and genome stability. Recent biochemical and genetic studies have clearly demonstrated that many aspects of chromatin, in addition to posttranslational modifications of histones, provide surfaces that can interact with effectors and the modifying machineries in a context-dependent manner, all as a part of the "chromatin signaling pathway." Here, we have reviewed recent findings on the molecular basis for the recruitment of the chromatin-modifying machineries and their diverse and varied biological outcomes.
AB - Posttranslational modifications of histones are coupled in the regulation of the cellular processes involving chromatin, such as transcription, replication, repair, and genome stability. Recent biochemical and genetic studies have clearly demonstrated that many aspects of chromatin, in addition to posttranslational modifications of histones, provide surfaces that can interact with effectors and the modifying machineries in a context-dependent manner, all as a part of the "chromatin signaling pathway." Here, we have reviewed recent findings on the molecular basis for the recruitment of the chromatin-modifying machineries and their diverse and varied biological outcomes.
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U2 - 10.1016/j.molcel.2010.11.031
DO - 10.1016/j.molcel.2010.11.031
M3 - Review article
C2 - 21145479
AN - SCOPUS:78649922622
VL - 40
SP - 689
EP - 701
JO - Molecular Cell
JF - Molecular Cell
SN - 1097-2765
IS - 5
ER -