The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target

Malini Rammohan, Ethan Harris, Rahul S. Bhansali, Emily Zhao, Loretta S. Li, John D. Crispino*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the evolutionarily conserved CMGC protein kinase superfamily. Due to its localization on chromosome 21, the biological significance of DYRK1A was initially characterized in the pathogenesis of Down syndrome (DS) and related neurodegenerative diseases. However, increasing evidence has demonstrated a prominent role in cancer through its ability to regulate biologic processes including cell cycle progression, DNA damage repair, transcription, ubiquitination, tyrosine kinase activity, and cancer stem cell maintenance. DYRK1A has been identified as both an oncogene and tumor suppressor in different models, underscoring the importance of cellular context in its function. Here, we review mechanistic contributions of DYRK1A to cancer biology and its role as a potential therapeutic target.

Original languageEnglish (US)
Pages (from-to)2003-2011
Number of pages9
JournalOncogene
Volume41
Issue number14
DOIs
StatePublished - Apr 1 2022

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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