The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity

R. Chawla, D. R. McCance, S. McKenna, I. S. Young, C. C. Patterson, J. Rangarajan, A. C. Reisetter, L. L. Armstrong, L. P. Lowe, B. E. Metzger, M. G. Hayes, D. M. Scholtens, W. L. Lowe*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Increased newborn adiposity is associated with later adverse metabolic outcomes. Previous genome-wide association studies (GWAS) demonstrated strong association of a locus on chromosome 3 (3q25.31) with newborn sum of skinfolds, a measure of overall adiposity. Whether this locus is associated with childhood adiposity is unknown. Genotype and sum of skinfolds data were available for 293 children at birth and age 2, and for 350 children at birth and age 6 from a European cohort (Belfast, UK) who participated in the Hyperglycemia and Adverse Pregnancy Outcome GWAS. We examined single nucleotide polymorphisms (SNPs) at the 3q25.31 locus associated with newborn adiposity. Linear regression analyses under an additive genetic model adjusting for maternal body mass index were performed. In both cohorts, a positive association was observed between all SNPs and sum of skinfolds at birth (P = 2.3 × 10-4, β = 0.026 and P = 4.8 × 10-4, β = 0.025). At the age of 2 years, a non-significant negative association was observed with sum of skinfolds (P = 0.06; β =-0.015). At the age of 6 years, there was no evidence of association (P = 0.86; β = 0.002). The 3q25.31 locus strongly associated with newborn adiposity had no significant association with childhood adiposity suggesting that its impact may largely be limited to fetal fat accretion.

Original languageEnglish (US)
Article numbere138
JournalNutrition and Diabetes
Volume4
Issue number9
DOIs
StatePublished - Jan 1 2014

    Fingerprint

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Chawla, R., McCance, D. R., McKenna, S., Young, I. S., Patterson, C. C., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Metzger, B. E., Hayes, M. G., Scholtens, D. M., & Lowe, W. L. (2014). The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity. Nutrition and Diabetes, 4(9), [e138]. https://doi.org/10.1038/nutd.2014.35