The circadian rhythm of lh release can be shifted by injections of a benzodiazepine in female golden hamsters

Fred W. Turek; Susan Losee-Olson

doi:10.1210/endo-122-2-756

The circadian rhythm of lh release can be shifted by injections of a benzodiazepine in female golden hamsters

Fred W. Turek, Susan Losee-Olson

Neurobiology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Three daily injections of the short-acting benzodiazepine, triazolam, induced pronounced phase shifts in the onset of both the circadlan surge in pituitary LH release and the circadian rhythm of locomotor activity in ovariectomized hamsters treated with estrogen. Both the magnitude and the direction of the phase shifts in these two rhythms were similar. These results indicate that a master circadian clock underlying diverse behavioral and endocrine rhythms can be reset by treatment with triazolam.

Original language	English (US)
Pages (from-to)	756-758
Number of pages	3
Journal	Endocrinology
Volume	122
Issue number	2
DOIs	https://doi.org/10.1210/endo-122-2-756
State	Published - Jul 23 1988

ASJC Scopus subject areas

Endocrinology

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10.1210/endo-122-2-756

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abstract = "Three daily injections of the short-acting benzodiazepine, triazolam, induced pronounced phase shifts in the onset of both the circadlan surge in pituitary LH release and the circadian rhythm of locomotor activity in ovariectomized hamsters treated with estrogen. Both the magnitude and the direction of the phase shifts in these two rhythms were similar. These results indicate that a master circadian clock underlying diverse behavioral and endocrine rhythms can be reset by treatment with triazolam.",

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N2 - Three daily injections of the short-acting benzodiazepine, triazolam, induced pronounced phase shifts in the onset of both the circadlan surge in pituitary LH release and the circadian rhythm of locomotor activity in ovariectomized hamsters treated with estrogen. Both the magnitude and the direction of the phase shifts in these two rhythms were similar. These results indicate that a master circadian clock underlying diverse behavioral and endocrine rhythms can be reset by treatment with triazolam.

AB - Three daily injections of the short-acting benzodiazepine, triazolam, induced pronounced phase shifts in the onset of both the circadlan surge in pituitary LH release and the circadian rhythm of locomotor activity in ovariectomized hamsters treated with estrogen. Both the magnitude and the direction of the phase shifts in these two rhythms were similar. These results indicate that a master circadian clock underlying diverse behavioral and endocrine rhythms can be reset by treatment with triazolam.

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The circadian rhythm of lh release can be shifted by injections of a benzodiazepine in female golden hamsters

Abstract

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