The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: Implications for anti-vasculogenic therapy

Anil K. Sood; Mavis S. Fletcher; Chris M. Zahn; Lynn M. Gruman; Jeremy E. Coffin; Elisabeth A. Seftor; Mary J.C. Hendrix

doi:10.4161/cbt.316

The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: Implications for anti-vasculogenic therapy

Anil K. Sood^*, Mavis S. Fletcher, Chris M. Zahn, Lynn M. Gruman, Jeremy E. Coffin, Elisabeth A. Seftor, Mary J.C. Hendrix

^*Corresponding author for this work

Robert H. Lurie Comprehensive Cancer Center

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detected in 23 (29.8%) tumors. The data show that tumor cell-lined vasculature was associated with aggressive tumor features and with shorter overall survival (p<0.001). Cox proportional hazards model revealed that tumor cell-lined vasculature (p=0.002) was independently associated with poor survival. This is the first study demonstrating the clinical implications of tumor cell-lined vasculature in ovarian carcinoma.

Original language	English (US)
Pages (from-to)	661-664
Number of pages	4
Journal	Cancer Biology and Therapy
Volume	1
Issue number	6
DOIs	https://doi.org/10.4161/cbt.316
State	Published - 2002

Keywords

Ovarian cancer
Prognosis
Tumor vasculature

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cbt.316

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@article{cb1dcacf57244107bdb2085ee08575b6,

title = "The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: Implications for anti-vasculogenic therapy",

abstract = "Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detected in 23 (29.8%) tumors. The data show that tumor cell-lined vasculature was associated with aggressive tumor features and with shorter overall survival (p<0.001). Cox proportional hazards model revealed that tumor cell-lined vasculature (p=0.002) was independently associated with poor survival. This is the first study demonstrating the clinical implications of tumor cell-lined vasculature in ovarian carcinoma.",

keywords = "Ovarian cancer, Prognosis, Tumor vasculature",

author = "Sood, {Anil K.} and Fletcher, {Mavis S.} and Zahn, {Chris M.} and Gruman, {Lynn M.} and Coffin, {Jeremy E.} and Seftor, {Elisabeth A.} and Hendrix, {Mary J.C.}",

note = "Funding Information: Portions of this work were funded by the Gynecologic Cancer Foundation/National Ovarian Cancer Coalition Ovarian Cancer Research Grant, the Phase II Junior Faculty Award (Reproductive Scientist Development Program) funded by the Burroughs Wellcome Fund and the UTMD Anderson Cancer Center SPORE in ovarian cancer (I P50 CA 83639) to A.K.S.; the Kate Daum Research Endowment and the Wallace Research Foundation Award to M.J.C.H.",

year = "2002",

doi = "10.4161/cbt.316",

language = "English (US)",

volume = "1",

pages = "661--664",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Landes Bioscience",

number = "6",

}

TY - JOUR

T1 - The clinical significance of tumor cell-lined vasculature in ovarian carcinoma

T2 - Implications for anti-vasculogenic therapy

AU - Sood, Anil K.

AU - Fletcher, Mavis S.

AU - Zahn, Chris M.

AU - Gruman, Lynn M.

AU - Coffin, Jeremy E.

AU - Seftor, Elisabeth A.

AU - Hendrix, Mary J.C.

N1 - Funding Information: Portions of this work were funded by the Gynecologic Cancer Foundation/National Ovarian Cancer Coalition Ovarian Cancer Research Grant, the Phase II Junior Faculty Award (Reproductive Scientist Development Program) funded by the Burroughs Wellcome Fund and the UTMD Anderson Cancer Center SPORE in ovarian cancer (I P50 CA 83639) to A.K.S.; the Kate Daum Research Endowment and the Wallace Research Foundation Award to M.J.C.H.

PY - 2002

Y1 - 2002

N2 - Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detected in 23 (29.8%) tumors. The data show that tumor cell-lined vasculature was associated with aggressive tumor features and with shorter overall survival (p<0.001). Cox proportional hazards model revealed that tumor cell-lined vasculature (p=0.002) was independently associated with poor survival. This is the first study demonstrating the clinical implications of tumor cell-lined vasculature in ovarian carcinoma.

AB - Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detected in 23 (29.8%) tumors. The data show that tumor cell-lined vasculature was associated with aggressive tumor features and with shorter overall survival (p<0.001). Cox proportional hazards model revealed that tumor cell-lined vasculature (p=0.002) was independently associated with poor survival. This is the first study demonstrating the clinical implications of tumor cell-lined vasculature in ovarian carcinoma.

KW - Ovarian cancer

KW - Prognosis

KW - Tumor vasculature

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JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 6

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The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: Implications for anti-vasculogenic therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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