The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation

Naveen Ashish, Marcas M. Bamman, Frank J. Cerny, Dan M. Cooper*, Pierre D'Hemecourt, Joey C. Eisenmann, Dawn Ericson, John Fahey, Bareket Falk, Davera Gabriel, Michael G. Kahn, Han C.G. Kemper, Szu Yun Leu, Robert I. Liem, Robert Mcmurray, Patricia A. Nixon, J. Tod Olin, Paolo T. Pianosi, Mary Purucker, Shlomit Radom-AizikAmy Taylor

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalClinical and Translational Science
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Innovation
Health
Medicine
Exercise
Research
Testing
Pediatrics
Biomarkers
Health care
Interoperability
Preventive Medicine
Translational Medical Research
Physical Fitness
Child Care
Child Health
Growth and Development
Reference Values
Therapeutics
Research Personnel
Clinical Trials

Keywords

  • Cardiopulmonary exercise testing
  • Clinical trials
  • Data harmonization
  • Exercise
  • Pediatrics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ashish, N., Bamman, M. M., Cerny, F. J., Cooper, D. M., D'Hemecourt, P., Eisenmann, J. C., ... Taylor, A. (2015). The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation. Clinical and Translational Science, 8(1), 67-76. https://doi.org/10.1111/cts.12194
Ashish, Naveen ; Bamman, Marcas M. ; Cerny, Frank J. ; Cooper, Dan M. ; D'Hemecourt, Pierre ; Eisenmann, Joey C. ; Ericson, Dawn ; Fahey, John ; Falk, Bareket ; Gabriel, Davera ; Kahn, Michael G. ; Kemper, Han C.G. ; Leu, Szu Yun ; Liem, Robert I. ; Mcmurray, Robert ; Nixon, Patricia A. ; Olin, J. Tod ; Pianosi, Paolo T. ; Purucker, Mary ; Radom-Aizik, Shlomit ; Taylor, Amy. / The Clinical Translation Gap in Child Health Exercise Research : A Call for Disruptive Innovation. In: Clinical and Translational Science. 2015 ; Vol. 8, No. 1. pp. 67-76.
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Ashish, N, Bamman, MM, Cerny, FJ, Cooper, DM, D'Hemecourt, P, Eisenmann, JC, Ericson, D, Fahey, J, Falk, B, Gabriel, D, Kahn, MG, Kemper, HCG, Leu, SY, Liem, RI, Mcmurray, R, Nixon, PA, Olin, JT, Pianosi, PT, Purucker, M, Radom-Aizik, S & Taylor, A 2015, 'The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation', Clinical and Translational Science, vol. 8, no. 1, pp. 67-76. https://doi.org/10.1111/cts.12194

The Clinical Translation Gap in Child Health Exercise Research : A Call for Disruptive Innovation. / Ashish, Naveen; Bamman, Marcas M.; Cerny, Frank J.; Cooper, Dan M.; D'Hemecourt, Pierre; Eisenmann, Joey C.; Ericson, Dawn; Fahey, John; Falk, Bareket; Gabriel, Davera; Kahn, Michael G.; Kemper, Han C.G.; Leu, Szu Yun; Liem, Robert I.; Mcmurray, Robert; Nixon, Patricia A.; Olin, J. Tod; Pianosi, Paolo T.; Purucker, Mary; Radom-Aizik, Shlomit; Taylor, Amy.

In: Clinical and Translational Science, Vol. 8, No. 1, 01.02.2015, p. 67-76.

Research output: Contribution to journalArticle

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AU - Ashish, Naveen

AU - Bamman, Marcas M.

AU - Cerny, Frank J.

AU - Cooper, Dan M.

AU - D'Hemecourt, Pierre

AU - Eisenmann, Joey C.

AU - Ericson, Dawn

AU - Fahey, John

AU - Falk, Bareket

AU - Gabriel, Davera

AU - Kahn, Michael G.

AU - Kemper, Han C.G.

AU - Leu, Szu Yun

AU - Liem, Robert I.

AU - Mcmurray, Robert

AU - Nixon, Patricia A.

AU - Olin, J. Tod

AU - Pianosi, Paolo T.

AU - Purucker, Mary

AU - Radom-Aizik, Shlomit

AU - Taylor, Amy

PY - 2015/2/1

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N2 - In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.

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