The CNS pericyte response to low oxygen: Early synthesis of cyclopentenone prostaglandins of the J-series

Paula Dore-Duffy*, Roumen Balabanov, Thomas Beaumont, Malkhan Katar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Exposure to low oxygen induces adaptive changes at the microvascular level that are beneficial to cell survival. These adaptive changes involve complex signaling mechanisms between the vascular endothelial cell and the pericyte, and are important to the maintenance of vascular homeostasis and hemostasis. We have investigated the early response of the central nervous system (CNS) microvascular pericyte to low oxygen. In vitro exposure of primary rat CNS pericytes to low oxygen induced the rapid synthesis and release of the cyclopentenone prostaglandin (PG) PGD2 and PGJ2 within 15-30 min following hypoxic stress signal. Hypoxia-induced release of PGD2/PGJ2 was COX-1 dependent and did not involve COX-2. The exogenous addition of 15-deoxyΔ 12,14 PGJ2 to pericytes under normoxic conditions increased glut-1 protein in the absence of hypoxia. PGD2 and PGJ2 may be early signaling molecules in the pericyte stress response.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalMicrovascular Research
Volume69
Issue number1-2
DOIs
StatePublished - Jan 2005

Keywords

  • Blood-brain barrier
  • COX-2
  • Central nervous system
  • Endothelial cell
  • Hypoxia
  • PGD2
  • PGJ2 and COX-1
  • Pericyte
  • Stress response prostaglandins

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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