The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Rupesh Agrawal; Dinesh Visva Gunasekeran; Aniruddha Agarwal; Ester Carreño; Kanika Aggarwal; Bhaskar Gupta; Dhananjay Raje; Somasheila I. Murthy; Mark Westcott; Soon Phaik Chee; Peter McCluskey; Ho Su Ling; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Carl P. Herbort; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Sarakshi Mahajan; Simona Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanya Abraham; Ruchi Vala; Joanne Lord; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Onn Min Kon; John Kempen; Emmett T. Cunningham; Andres Rousselot; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2018.1489061

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ester Carreño, Kanika Aggarwal, Bhaskar Gupta, Dhananjay Raje, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas JonesIlknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Joanne Lord, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, John Kempen, Emmett T. Cunningham, Andres Rousselot, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Original language	English (US)
Pages (from-to)	38-48
Number of pages	11
Journal	Ocular Immunology and Inflammation
Volume	28
Issue number	sup1
DOIs	https://doi.org/10.1080/09273948.2018.1489061
State	Published - 2020

Funding

The research was partially funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. This sponsor supported some of the research man-hours that were contributed by all our part-time collaborators from the Moorfields Eye Hospital that are salaried as Ophthalmology clinicians by the hospital. Debra A. Goldstein is supported by an unrestricted grant from Research to Prevent Blindness (RPB). Vishali Gupta is supported by grant from Department of Biotechnology (DBT), India. Julio J Gonalez-Lopez is supported by study grants from AbbVie, Allergan, and Angelini.

Keywords

Anti-tubercular therapy
choroiditis
ocular
tuberculosis
uveitis

ASJC Scopus subject areas

Ophthalmology
Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/09273948.2018.1489061

Cite this

Agrawal, R., Gunasekeran, D. V., Agarwal, A., Carreño, E., Aggarwal, K., Gupta, B., Raje, D., Murthy, S. I., Westcott, M., Chee, S. P., McCluskey, P., Ling, H. S., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., Khairallah, M., ... Gupta, V. (2020). The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. Ocular Immunology and Inflammation, 28(sup1), 38-48. https://doi.org/10.1080/09273948.2018.1489061

@article{c367bcdc1dc74614bc31cb7931cea8f1,

title = "The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis",

abstract = "Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.",

keywords = "Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis",

author = "Rupesh Agrawal and Gunasekeran, {Dinesh Visva} and Aniruddha Agarwal and Ester Carre{\~n}o and Kanika Aggarwal and Bhaskar Gupta and Dhananjay Raje and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter McCluskey and Ling, {Ho Su} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Sarakshi Mahajan and Simona Esposti and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanya Abraham and Ruchi Vala and Joanne Lord and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and John Kempen and Cunningham, {Emmett T.} and Andres Rousselot and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright}, Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2018.1489061",

language = "English (US)",

volume = "28",

pages = "38--48",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "sup1",

}

Agrawal, R, Gunasekeran, DV, Agarwal, A, Carreño, E, Aggarwal, K, Gupta, B, Raje, D, Murthy, SI, Westcott, M, Chee, SP, McCluskey, P, Ling, HS, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Mahajan, S, Esposti, S, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Lord, J, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Kempen, J, Cunningham, ET, Rousselot, A, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis', Ocular Immunology and Inflammation, vol. 28, no. sup1, pp. 38-48. https://doi.org/10.1080/09273948.2018.1489061

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. / Agrawal, Rupesh; Gunasekeran, Dinesh Visva; Agarwal, Aniruddha et al.
In: Ocular Immunology and Inflammation, Vol. 28, No. sup1, 2020, p. 38-48.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

AU - Agrawal, Rupesh

AU - Gunasekeran, Dinesh Visva

AU - Agarwal, Aniruddha

AU - Carreño, Ester

AU - Aggarwal, Kanika

AU - Gupta, Bhaskar

AU - Raje, Dhananjay

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - McCluskey, Peter

AU - Ling, Ho Su

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Mahajan, Sarakshi

AU - Esposti, Simona

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanya

AU - Vala, Ruchi

AU - Lord, Joanne

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Kempen, John

AU - Cunningham, Emmett T.

AU - Rousselot, Andres

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

AB - Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

KW - Anti-tubercular therapy

KW - choroiditis

KW - ocular

KW - tuberculosis

KW - uveitis

UR - http://www.scopus.com/inward/record.url?scp=85053279767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053279767&partnerID=8YFLogxK

U2 - 10.1080/09273948.2018.1489061

DO - 10.1080/09273948.2018.1489061

M3 - Article

C2 - 30156979

AN - SCOPUS:85053279767

SN - 0927-3948

VL - 28

SP - 38

EP - 48

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - sup1

ER -

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this