The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends

Aniruddha Agarwal, Rupesh Agrawal, Dinesh Visva Gunasekaran, Dhananjay Raje, Bhaskar Gupta, Kanika Aggarwal, Somasheila L. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-TutkunKalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett Cunningham, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.

Original languageEnglish (US)
Pages (from-to)465-473
Number of pages9
JournalOcular Immunology and Inflammation
Volume27
Issue number3
DOIs
StatePublished - Apr 3 2019

Keywords

  • Anti-tubercular therapy
  • choroidal tuberculoma
  • choroiditis
  • polymerase chain reaction
  • tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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