The complexation properties of some unnatural and natural macrocyclic trichothecenes

Derek W. Anderson*, Peter R. Ashton, Robin M. Black, David A. Leigh, Alexandra M Z Slawin, J. Fraser Stoddart, David J. Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

As a result of investigating the complexing properties of a series of novel polyether analogues (3)-(9) of macrocyclic trichothecenes towards alkali metal cations and RNH3+ ions, it has been proposed, with supporting evidence from X-ray crystallography on verrucarin A (1) and fast atom bombardment mass spectrometry of complexes involving (1) and the triacetate (10) of baccharinol B4 (11), that the enhanced biological activities of macrocyclic trichothecenes, such as (1) and (11), compared with non-macrocyclic trichoverroids such as (2), may be a consequence of their abilities to bind to NH3+ ionic sites on proteins, particularly those associated with the 60S ribosomes.

Original languageEnglish (US)
Pages (from-to)904-908
Number of pages5
JournalJournal of the Chemical Society, Chemical Communications
Issue number13
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Molecular Medicine

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