The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis

Karan Sud, Navneet Narula*, Elena Aikawa, Eloisa Arbustini, Philippe Pibarot, Giampaolo Merlini, Robert S. Rosenson, Surya V. Seshan, Edgar Argulian, Amir Ahmadi, Fang Zhou, Andre L. Moreira, Nancy Côté, Sotirios Tsimikas, Valentin Fuster, Sam Gandy, Robert O. Bonow, Olga Gursky, Jagat Narula

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Calcific aortic valve disease (CAVD) and stenosis have a complex pathogenesis, and no therapies are available that can halt or slow their progression. Several studies have shown the presence of apolipoprotein-related amyloid deposits in close proximity to calcified areas in diseased aortic valves. In this Perspective, we explore a possible relationship between amyloid deposits, calcification and the development of aortic valve stenosis. These amyloid deposits might contribute to the amplification of the inflammatory cycle in the aortic valve, including extracellular matrix remodelling and myofibroblast and osteoblast-like cell proliferation. Further investigation in this area is needed to characterize the amyloid deposits associated with CAVD, which could allow the use of antisense oligonucleotides and/or isotype gene therapies for the prevention and/or treatment of CAVD.

Original languageEnglish (US)
Pages (from-to)418-428
Number of pages11
JournalNature Reviews Cardiology
Issue number6
StatePublished - Jun 2023

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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