Abstract
Autoreactive B cells can promote autoimmunity through antigen presentation to autoreactive T cells, production of autoantibodies, generation of cytokines promoting T cell activation and differentiation, and inhibition of regulatory T cells and B cells. Here, the authors highlight studies pertaining to B cell mechanisms associated with disease pathogenesis and outcomes in autoimmune hepatitis and the immune-mediated cholangiopathies (primary biliary cholangitis, primary sclerosing cholangitis, and biliary atresia). The vast majority of investigations focus on autoantibodies and future research endeavors should include deciphering the role of the B cell in T cell activation (through antigen presentation, cytokine/chemokine production, and inhibition of regulation). Targeting B cell mechanisms in the treatment of autoimmune liver diseases is also highlighted.
Original language | English (US) |
---|---|
Pages (from-to) | 422-431 |
Number of pages | 10 |
Journal | Seminars in Liver Disease |
Volume | 39 |
Issue number | 4 |
DOIs | |
State | Published - 2019 |
Keywords
- antigen presentation
- autoantibody
- autoimmune hepatitis
- biliary atresia
- immunity
- primary biliary cholangitis
- primary sclerosing cholangitis
ASJC Scopus subject areas
- Hepatology