The Contribution of B Cells in Autoimmune Liver Diseases

Sarah A. Taylor, David N. Assis, Cara L. MacK*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Autoreactive B cells can promote autoimmunity through antigen presentation to autoreactive T cells, production of autoantibodies, generation of cytokines promoting T cell activation and differentiation, and inhibition of regulatory T cells and B cells. Here, the authors highlight studies pertaining to B cell mechanisms associated with disease pathogenesis and outcomes in autoimmune hepatitis and the immune-mediated cholangiopathies (primary biliary cholangitis, primary sclerosing cholangitis, and biliary atresia). The vast majority of investigations focus on autoantibodies and future research endeavors should include deciphering the role of the B cell in T cell activation (through antigen presentation, cytokine/chemokine production, and inhibition of regulation). Targeting B cell mechanisms in the treatment of autoimmune liver diseases is also highlighted.

Original languageEnglish (US)
Pages (from-to)422-431
Number of pages10
JournalSeminars in Liver Disease
Volume39
Issue number4
DOIs
StatePublished - 2019

Keywords

  • antigen presentation
  • autoantibody
  • autoimmune hepatitis
  • biliary atresia
  • immunity
  • primary biliary cholangitis
  • primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology

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