The controversial role of microglia in malignant gliomas

Jun Wei, Konrad Gabrusiewicz, Amy Heimberger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations


Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.

Original languageEnglish (US)
Article number285246
JournalClinical and Developmental Immunology
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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