TY - CHAP
T1 - The cooperative roles of Foxcl and Foxc2 in cardiovascular development
AU - Kume, Tsutomu
PY - 2009
Y1 - 2009
N2 - Foxcl and Foxc2 are closelyrelated members ofthe Forkhead/Fox transcription factor family. The two Foxc genes have overlapping expression patterns in mesodermal and neural crest derivatives during development, as well as similar functions ofgene regulation. Consistently, mouse mutants for each gene have similar abnormalities in multiple embryonic tissues, including the eye, kidney and cardiovascular system. Analysis of compound Foxc1; Foxc2 mutant embryos reveals that the two Foxc genes have dose-dependent, cooperative roles in development. In particular, recent studies demonstrate that Foxcl and Foxc2 are essential for arterial cell specification , lymphatic vessel formation, angiogenesis and cardiac outflow tract development. This chapter will summarize and discuss current knowledge about the function ofFoxcl and Foxc2 in cardiovascular development.
AB - Foxcl and Foxc2 are closelyrelated members ofthe Forkhead/Fox transcription factor family. The two Foxc genes have overlapping expression patterns in mesodermal and neural crest derivatives during development, as well as similar functions ofgene regulation. Consistently, mouse mutants for each gene have similar abnormalities in multiple embryonic tissues, including the eye, kidney and cardiovascular system. Analysis of compound Foxc1; Foxc2 mutant embryos reveals that the two Foxc genes have dose-dependent, cooperative roles in development. In particular, recent studies demonstrate that Foxcl and Foxc2 are essential for arterial cell specification , lymphatic vessel formation, angiogenesis and cardiac outflow tract development. This chapter will summarize and discuss current knowledge about the function ofFoxcl and Foxc2 in cardiovascular development.
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U2 - 10.1007/978-1-4419-1599-3_5
DO - 10.1007/978-1-4419-1599-3_5
M3 - Chapter
C2 - 20429416
AN - SCOPUS:77952491164
SN - 9781441915986
T3 - Advances in Experimental Medicine and Biology
SP - 63
EP - 77
BT - Forkhead Transcription Factors
PB - Springer New York LLC
ER -