The cooperative roles of Foxcl and Foxc2 in cardiovascular development

Tsutomu Kume*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Scopus citations


Foxcl and Foxc2 are closelyrelated members ofthe Forkhead/Fox transcription factor family. The two Foxc genes have overlapping expression patterns in mesodermal and neural crest derivatives during development, as well as similar functions ofgene regulation. Consistently, mouse mutants for each gene have similar abnormalities in multiple embryonic tissues, including the eye, kidney and cardiovascular system. Analysis of compound Foxc1; Foxc2 mutant embryos reveals that the two Foxc genes have dose-dependent, cooperative roles in development. In particular, recent studies demonstrate that Foxcl and Foxc2 are essential for arterial cell specification , lymphatic vessel formation, angiogenesis and cardiac outflow tract development. This chapter will summarize and discuss current knowledge about the function ofFoxcl and Foxc2 in cardiovascular development.

Original languageEnglish (US)
Title of host publicationForkhead Transcription Factors
Subtitle of host publicationVital Elements in Biology and Medicine
PublisherSpringer New York LLC
Number of pages15
ISBN (Print)9781441915986
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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