The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8

Donald M. Lloyd-Jones*, Cora E. Lewis, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Jared P. Reis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The CARDIA (Coronary Artery Risk Development in Young Adults) study began in 1985 to 1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 years from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of the contemporary epidemiology and life course of cardiovascular health and disease, as well as pulmonary, renal, neurological, and other manifestations of aging. CARDIA has established associations between the neighborhood environment and the evolution of lifestyle behaviors with biological risk factors, subclinical disease, and early clinical events. CARDIA has also identified the nature and major determinants of Black-White differences in the development of cardiovascular risk. CARDIA will continue to be a unique resource for understanding determinants, mechanisms, and outcomes of cardiovascular health and disease across the life course, leveraging ongoing pan-omics work from genomics to metabolomics that will define mechanistic pathways involved in cardiometabolic aging.

Original languageEnglish (US)
Pages (from-to)260-277
Number of pages18
JournalJournal of the American College of Cardiology
Issue number3
StatePublished - Jul 20 2021


  • cardiovascular disease
  • cardiovascular health
  • cardiovascular risk factors
  • race
  • social determinants of health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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