The Curious Case of Bivalent Marks

Hans Martin Herz, Shima Nakanishi, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations


Bivalently marked chromatin, containing both histone H3 lysine 4 (H3K4) and H3K27 trimethylation, is a hallmark of developmentally regulated paused promoters in mammalian embryonic stem cells. In this issue of Developmental Cell, Akkers et al. report that Xenopus tropicalis embryos transition through early development without the requirement for bivalently marked promoters.

Original languageEnglish (US)
Pages (from-to)301-303
Number of pages3
JournalDevelopmental Cell
Issue number3
StatePublished - Sep 15 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


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