The CXCL8-CXCR1/2 pathways in cancer

Qian Liu, Anping Li, Yijun Tian, Jennifer D. Wu, Yu Liu, Tengfei Li, Yuan Chen, Xinwei Han, Kongming Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

155 Scopus citations

Abstract

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and tumour progression. C-X-C motif ligand 8 (CXCL8) is a chemokine that acts as an important multifunctional cytokine to modulate tumour proliferation, invasion and migration in an autocrine or paracrine manner. Studies have suggested that CXCL8 and its cognate receptors, C-X-C chemokine receptor 1 (CXCR1) and C-X-C chemokine receptor 2 (CXCR2), mediate the initiation and development of various cancers including breast cancer, prostate cancer, lung cancer, colorectal carcinoma and melanoma. CXCL8 also integrates with multiple intracellular signalling pathways to produce coordinated effects. Neovascularisation, which provides a basis for fostering tumour growth and metastasis, is now recognised as a critical function of CXCL8 in the tumour microenvironment. In this review, we summarize the biological functions and clinical significance of the CXCL8 signalling axis in cancer. We also propose that CXCL8 may be a potential therapeutic target for cancer treatment.

Original languageEnglish (US)
Pages (from-to)61-71
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume31
DOIs
StatePublished - Oct 1 2016

Keywords

  • Angiogenesis
  • CXCL8
  • CXCR1
  • CXCR2
  • Cancer
  • Metastasis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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