The death effector domain protein family

Bryan C. Barnhart, Justine C. Lee, Elizabeth C. Alappat, Marcus E. Peter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Apoptosis signaling is regulated and executed by specialized proteins that often carry protein/protein interaction domains. One of these domains is the death effector domain (DED) that is predominantly found in components of the death-inducing signaling complex, which forms at the members of the death receptor family following their ligation. Both proapoptotic- and antiapoptotic-DED-containing proteins have been identified, which makes these proteins exquisitely suited to the regulation of apoptosis. Aside from their pivotal role in the control of the apoptotic program, DED-containing proteins have recently been demonstrated to exert their influence on other cellular processes as well, including cell proliferation. These data highlight the multiple roles for the members of this family, suggesting that they are suited to control both life and death decisions of cells. Additionally, because they can act proapoptotically, antiapoptotically, or in the regulation of the cell cycle, this family of proteins may be excellent candidates for cancer therapy targets.

Original languageEnglish (US)
Pages (from-to)8634-8644
Number of pages11
JournalOncogene
Volume22
Issue number53 REV. ISS. 7
DOIs
StatePublished - Nov 24 2003

Keywords

  • Apoptosis
  • Cancer
  • DD fold

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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