Abstract
One hundred and ten patients with Philadelphia chromosome (Ph)-positive chronic phase chronic myelogenous leukemia (CML) post-interferon-α failure treated with imatinib mesylate therapy were analyzed for the prognostic significance of marrow reticulin stain-measured fibrosis. The median time from diagnosis was 31 months. Severe reticulin (grade 3-4) fibrosis was observed in 67 patients (61%). Patients with severe marrow fibrosis had similar complete cytogenetic response rates with imatinib (67 vs. 58%; P=0.45) compared with those with mild-moderate fibrosis. The estimated 4 year survival rates (80 vs. 88%; P=0.27) and failure-free survival rates (69 vs. 77%; P=0.34) were also not different. We conclude that the previously established poor prognostic significance of marrow fibrosis in CML is less relevant with imatinib therapy.
Original language | English (US) |
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Pages (from-to) | 993-997 |
Number of pages | 5 |
Journal | Leukemia and Lymphoma |
Volume | 46 |
Issue number | 7 |
DOIs | |
State | Published - 2005 |
Keywords
- Chronic myelogenous leukemia (CML)
- Imatinib mesylate
- Marrow fibrosis
- Philadelphia chromosome-positive chronic phase
- Prognostic significance
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research