The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity

Ferdinand Kappes, Tanja Waldmann, Veena Mathew, Jindan Yu, Ling Zhang, Michael S. Khodadoust, Arul M. Chinnaiyan, Karolin Luger, Sylvia Erhardt, Robert Schneider, David M. Markovitz

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Heterochromatin integrity is crucial for genome stability and regulation of gene expression, but the factors involved in mammalian heterochromatin biology are only incompletely understood. Here we identify the oncoprotein DEK, an abundant nuclear protein with a previously enigmatic in vivo function, as a Suppressor of Variegation [Su(var)] that is crucial to global heterochromatin integrity. We show that DEK interacts directly with Heterochromatin Protein 1 a (HP1a) and markedly enhances its binding to trimethylated H3K9 (H3K9me3), which is key for maintaining heterochromatic regions. Loss of Dek in Drosophila leads to a Su(var) phenotype and global reduction in heterochromatin. Thus, these findings show that DEK is a key factor in maintaining the balance between heterochromatin and euchromatin in vivo.

Original languageEnglish (US)
Pages (from-to)673-678
Number of pages6
JournalGenes and Development
Volume25
Issue number7
DOIs
Publication statusPublished - Apr 1 2011

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Keywords

  • Epigenetics
  • HP1-α
  • Heterochromatin
  • Oncogene
  • Su(var)

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Kappes, F., Waldmann, T., Mathew, V., Yu, J., Zhang, L., Khodadoust, M. S., ... Markovitz, D. M. (2011). The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Genes and Development, 25(7), 673-678. https://doi.org/10.1101/gad.2036411