The demographics of adverse outcomes in cystic fibrosis

Meghan E. McGarry; Wadsworth A. Williams; Susanna A. McColley

doi:10.1002/ppul.24434

The demographics of adverse outcomes in cystic fibrosis

Meghan E. McGarry^*, Wadsworth A. Williams, Susanna A. McColley

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Understanding variability in cystic fibrosis (CF) health outcomes requires an understanding of factors that go far beyond Cystic Fibrosis Transmembrane Receptor (CFTR) function caused by different gene mutations. Social and environmental factors that influence health have a significant influence on the trajectory of health in CF and in other chronic diseases. In this article, we review demographic factors associated with poorer health outcomes in CF, known and postulated biological mechanisms of these outcomes, and interventions that healthcare teams can implement that may reduce outcome disparities.

Original language	English (US)
Pages (from-to)	S74-S83
Journal	Pediatric Pulmonology
Volume	54
Issue number	S3
DOIs	https://doi.org/10.1002/ppul.24434
State	Published - Nov 1 2019

Funding

MEM is supported by the NHLBI (1K23HL133437‐01A1) and Cystic Fibrosis Foundation Therapeutics (MCGARR16A0). SAM is supported by the Northwestern University Clinical and Translational Sciences Institute through the National Center for Advancing Translational Sciences (UL1TR001422).

Keywords

cystic fibrosis
epidemiology
social dimensions of pulmonary medicine

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ppul.24434

Cite this

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abstract = "Understanding variability in cystic fibrosis (CF) health outcomes requires an understanding of factors that go far beyond Cystic Fibrosis Transmembrane Receptor (CFTR) function caused by different gene mutations. Social and environmental factors that influence health have a significant influence on the trajectory of health in CF and in other chronic diseases. In this article, we review demographic factors associated with poorer health outcomes in CF, known and postulated biological mechanisms of these outcomes, and interventions that healthcare teams can implement that may reduce outcome disparities.",

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AU - McColley, Susanna A.

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N2 - Understanding variability in cystic fibrosis (CF) health outcomes requires an understanding of factors that go far beyond Cystic Fibrosis Transmembrane Receptor (CFTR) function caused by different gene mutations. Social and environmental factors that influence health have a significant influence on the trajectory of health in CF and in other chronic diseases. In this article, we review demographic factors associated with poorer health outcomes in CF, known and postulated biological mechanisms of these outcomes, and interventions that healthcare teams can implement that may reduce outcome disparities.

AB - Understanding variability in cystic fibrosis (CF) health outcomes requires an understanding of factors that go far beyond Cystic Fibrosis Transmembrane Receptor (CFTR) function caused by different gene mutations. Social and environmental factors that influence health have a significant influence on the trajectory of health in CF and in other chronic diseases. In this article, we review demographic factors associated with poorer health outcomes in CF, known and postulated biological mechanisms of these outcomes, and interventions that healthcare teams can implement that may reduce outcome disparities.

KW - cystic fibrosis

KW - epidemiology

KW - social dimensions of pulmonary medicine

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The demographics of adverse outcomes in cystic fibrosis

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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