The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles

Cynthia M. Hong, Alexander V. Statsyuk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles.

Original languageEnglish (US)
Pages (from-to)2932-2935
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number18
DOIs
StatePublished - May 14 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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