The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device-based treatment of sudden cardiac arrest

Amy E. Thompson*, Brett Atwater, Lucas Boersma, Ian Crozier, Gregory Engel, Paul Friedman, J. Rod Gimbel, Bradley P. Knight, Jaimie Manlucu, Francis Murgatroyd, David O'Donnell, Juergen Kuschyk, Paul DeGroot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Introduction: The extravascular implantable cardioverter-defibrillato (EV ICD) system with substernal lead placement is a novel nontransvenous alternative to current commercially available ICD systems. The EV ICD provides defibrillation and pacing therapies without the potential long-term complications of endovascular lead placement but requires a new procedure for implantation with a safety profile under evaluation. Methods: This paper summarizes the development of the EV ICD, including the preclinical and clinical evaluations that have contributed to the system and procedural refinements to date. Results: Extensive preclinical research evaluations and four human clinical studies with >140 combined acute and chronic implants have enabled the development and refinement of the EV ICD system, currently in worldwide pivotal study. Conclusion: The EV ICD may represent a clinically valuable solution in protecting patients from sudden cardiac death while avoiding the long-term consequences of transvenous hardware. The EV ICD offers advantages over transvenous and subcutaneous systems by avoiding placement in the heart and vasculature; relative to subcutaneous systems, EV ICD requires less energy for defibrillation, enabling a smaller device, and provides pacing features such as antitachycardia and asystole pacing in a single system.

Original languageEnglish (US)
Pages (from-to)1085-1095
Number of pages11
JournalJournal of cardiovascular electrophysiology
Volume33
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • ICD
  • anterior mediastinum
  • arrhythmia
  • extravascular
  • substernal

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device-based treatment of sudden cardiac arrest'. Together they form a unique fingerprint.

Cite this