The Disc Sign in Sickling Hemoglobinopathies

Michael H. Goldbaum, Lee M. Jampol*, Morton F. Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The disc sign is the presence of dark red spots on the optic disc of patients with a sickling hemoglobinopathy. The dark spots appear to be plugs of deoxygenated erythrocytes in small surface disc vessels. The occlusions, which are transient and do not produce clinically detectable visual impairment, were seen most often in patients with homozygous sickle cell anemia and may be the result of clogging of small vessels by irreversibly sickled erythrocytes.

Original languageEnglish (US)
Pages (from-to)1597-1600
Number of pages4
JournalArchives of ophthalmology
Issue number9
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Ophthalmology


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