The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor

Colin K. Franz; Nikhil K. Murthy; George R. Malik; Jean W. Kwak; Dom D’Andrea; Alexis R. Wolfe; Ellen Farr; Melanie A. Stearns; Swati Deshmukh; Jinny O. Tavee; Fang Sun; Kevin N. Swong; Leslie Rydberg; R. James Cotton; Lisa F. Wolfe; James M. Walter; John M. Coleman; John A. Rogers

doi:10.1186/s12984-022-01089-1

The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor

Colin K. Franz^*, Nikhil K. Murthy, George R. Malik, Jean W. Kwak, Dom D’Andrea, Alexis R. Wolfe, Ellen Farr, Melanie A. Stearns, Swati Deshmukh, Jinny O. Tavee, Fang Sun, Kevin N. Swong, Leslie Rydberg, R. James Cotton, Lisa F. Wolfe, James M. Walter, John M. Coleman, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We diagnosed 66 peripheral nerve injuries in 34 patients who survived severe coronavirus disease 2019 (COVID-19). We combine this new data with published case series re-analyzed here (117 nerve injuries; 58 patients) to provide a comprehensive accounting of lesion sites. The most common are ulnar (25.1%), common fibular (15.8%), sciatic (13.1%), median (9.8%), brachial plexus (8.7%) and radial (8.2%) nerves at sites known to be vulnerable to mechanical loading. Protection of peripheral nerves should be prioritized in the care of COVID-19 patients. To this end, we report proof of concept data of the feasibility for a wearable, wireless pressure sensor to provide real time monitoring in the intensive care unit setting.

Original language	English (US)
Article number	108
Journal	Journal of neuroengineering and rehabilitation
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12984-022-01089-1
State	Published - Dec 2022

Funding

We would like to acknowledge Dr. Richard G Wunderink, MD (Professor, Pulmonary and Critical Care, Northwestern Feinberg School of Medicine) and Helen Donnelly, RN (Clinical Research Nurse, Pulmonary and Critical Care, Northwestern Feinberg School of Medicine) for assisting us with patient recruitment for our pressure sensor studies. We would like to acknowledge Peggy Kirk, RN (President and Chief Executive Officer, Shirley Ryan AbilityLab) for supporting this project as a part of a continuous quality improvement to enhance patient safety and outcomes. CKF acknowledges the generous support of the Belle Carnell Regenerative Neurorehabilitation fund and the American Neuromuscular Foundation (Development Grant). We would like to acknowledge Dr. Richard G Wunderink, MD (Professor, Pulmonary and Critical Care, Northwestern Feinberg School of Medicine) and Helen Donnelly, RN (Clinical Research Nurse, Pulmonary and Critical Care, Northwestern Feinberg School of Medicine) for assisting us with patient recruitment for our pressure sensor studies. We would like to acknowledge Peggy Kirk, RN (President and Chief Executive Officer, Shirley Ryan AbilityLab) for supporting this project as a part of a continuous quality improvement to enhance patient safety and outcomes. CKF acknowledges the generous support of the Belle Carnell Regenerative Neurorehabilitation fund and the American Neuromuscular Foundation (Development Grant).

Keywords

Brachial plexus
COVID-19
Intensive care unit
Neuromuscular
Neuropathy
Peripheral nerve injury
Rehabilitation
Wearable sensor

ASJC Scopus subject areas

Rehabilitation
Health Informatics

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Franz, C. K., Murthy, N. K., Malik, G. R., Kwak, J. W., D’Andrea, D., Wolfe, A. R., Farr, E., Stearns, M. A., Deshmukh, S., Tavee, J. O., Sun, F., Swong, K. N., Rydberg, L., Cotton, R. J., Wolfe, L. F., Walter, J. M., Coleman, J. M., & Rogers, J. A. (2022). The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor. Journal of neuroengineering and rehabilitation, 19(1), Article 108. https://doi.org/10.1186/s12984-022-01089-1

Franz, Colin K. ; Murthy, Nikhil K. ; Malik, George R. et al. / The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy : a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor. In: Journal of neuroengineering and rehabilitation. 2022 ; Vol. 19, No. 1.

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title = "The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor",

abstract = "We diagnosed 66 peripheral nerve injuries in 34 patients who survived severe coronavirus disease 2019 (COVID-19). We combine this new data with published case series re-analyzed here (117 nerve injuries; 58 patients) to provide a comprehensive accounting of lesion sites. The most common are ulnar (25.1%), common fibular (15.8%), sciatic (13.1%), median (9.8%), brachial plexus (8.7%) and radial (8.2%) nerves at sites known to be vulnerable to mechanical loading. Protection of peripheral nerves should be prioritized in the care of COVID-19 patients. To this end, we report proof of concept data of the feasibility for a wearable, wireless pressure sensor to provide real time monitoring in the intensive care unit setting.",

keywords = "Brachial plexus, COVID-19, Intensive care unit, Neuromuscular, Neuropathy, Peripheral nerve injury, Rehabilitation, Wearable sensor",

author = "Franz, {Colin K.} and Murthy, {Nikhil K.} and Malik, {George R.} and Kwak, {Jean W.} and Dom D{\textquoteright}Andrea and Wolfe, {Alexis R.} and Ellen Farr and Stearns, {Melanie A.} and Swati Deshmukh and Tavee, {Jinny O.} and Fang Sun and Swong, {Kevin N.} and Leslie Rydberg and Cotton, {R. James} and Wolfe, {Lisa F.} and Walter, {James M.} and Coleman, {John M.} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s12984-022-01089-1",

language = "English (US)",

volume = "19",

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Franz, CK, Murthy, NK, Malik, GR, Kwak, JW, D’Andrea, D, Wolfe, AR, Farr, E, Stearns, MA, Deshmukh, S, Tavee, JO, Sun, F, Swong, KN , Rydberg, L , Cotton, RJ , Wolfe, LF , Walter, JM , Coleman, JM & Rogers, JA 2022, 'The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor', Journal of neuroengineering and rehabilitation, vol. 19, no. 1, 108. https://doi.org/10.1186/s12984-022-01089-1

The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor. / Franz, Colin K.; Murthy, Nikhil K.; Malik, George R. et al.
In: Journal of neuroengineering and rehabilitation, Vol. 19, No. 1, 108, 12.2022.

Research output: Contribution to journal › Article › peer-review

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T1 - The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy

T2 - a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor

AU - Franz, Colin K.

AU - Murthy, Nikhil K.

AU - Malik, George R.

AU - Kwak, Jean W.

AU - D’Andrea, Dom

AU - Wolfe, Alexis R.

AU - Farr, Ellen

AU - Stearns, Melanie A.

AU - Deshmukh, Swati

AU - Tavee, Jinny O.

AU - Sun, Fang

AU - Swong, Kevin N.

AU - Rydberg, Leslie

AU - Cotton, R. James

AU - Wolfe, Lisa F.

AU - Walter, James M.

AU - Coleman, John M.

AU - Rogers, John A.

PY - 2022/12

Y1 - 2022/12

N2 - We diagnosed 66 peripheral nerve injuries in 34 patients who survived severe coronavirus disease 2019 (COVID-19). We combine this new data with published case series re-analyzed here (117 nerve injuries; 58 patients) to provide a comprehensive accounting of lesion sites. The most common are ulnar (25.1%), common fibular (15.8%), sciatic (13.1%), median (9.8%), brachial plexus (8.7%) and radial (8.2%) nerves at sites known to be vulnerable to mechanical loading. Protection of peripheral nerves should be prioritized in the care of COVID-19 patients. To this end, we report proof of concept data of the feasibility for a wearable, wireless pressure sensor to provide real time monitoring in the intensive care unit setting.

AB - We diagnosed 66 peripheral nerve injuries in 34 patients who survived severe coronavirus disease 2019 (COVID-19). We combine this new data with published case series re-analyzed here (117 nerve injuries; 58 patients) to provide a comprehensive accounting of lesion sites. The most common are ulnar (25.1%), common fibular (15.8%), sciatic (13.1%), median (9.8%), brachial plexus (8.7%) and radial (8.2%) nerves at sites known to be vulnerable to mechanical loading. Protection of peripheral nerves should be prioritized in the care of COVID-19 patients. To this end, we report proof of concept data of the feasibility for a wearable, wireless pressure sensor to provide real time monitoring in the intensive care unit setting.

KW - Brachial plexus

KW - COVID-19

KW - Intensive care unit

KW - Neuromuscular

KW - Neuropathy

KW - Peripheral nerve injury

KW - Rehabilitation

KW - Wearable sensor

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DO - 10.1186/s12984-022-01089-1

M3 - Article

C2 - 36209094

AN - SCOPUS:85139404904

SN - 1743-0003

VL - 19

JO - Journal of neuroengineering and rehabilitation

JF - Journal of neuroengineering and rehabilitation

IS - 1

M1 - 108

ER -

Franz CK, Murthy NK, Malik GR, Kwak JW, D’Andrea D, Wolfe AR et al. The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor. Journal of neuroengineering and rehabilitation. 2022 Dec;19(1):108. doi: 10.1186/s12984-022-01089-1

The distribution of acquired peripheral nerve injuries associated with severe COVID-19 implicate a mechanism of entrapment neuropathy: a multicenter case series and clinical feasibility study of a wearable, wireless pressure sensor

Abstract

Funding

Keywords

ASJC Scopus subject areas

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