The Drosophila Roughened mutation: Activation of a rap homolog disrupts eye development and interferes with cell determination

Iswar K. Hariharan*, Richard W. Carthew, Gerald M. Rubin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Roughened is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photoreceptor cell determination. Roughened is a dominant gain-of-function mutation that results from a single amino acid change (Phe157 to Leu) in the Drosophila Rap1 protein. Loss of function Rap1 mutations are lethal. Drosophila Rap1 protein is 88% identical to human rap1A/K-rev1 protein, a putative antagonist of ras action.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalCell
Volume67
Issue number4
DOIs
StatePublished - Nov 15 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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