The DSM-IV field trial for mixed anxiety-depression

Richard E. Zinbarg*, David H. Barlow, Michael Liebowitz, Linda Street, Eugene Broadhead, Wayne Katon, Peter Roy-Byrne, Jean Pierre Lepine, Mardjan Teherani, Jeff Richards, Phillip J. Brantley, Helena Kraemer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Objective: This field trial was designed to answer four questions. First, are patients presenting with anxious or depressed symptoms that are associated with significant impairment but do not meet DSM-III-R definitional thresholds for axis 1 anxiety or mood disorders? Second, is the impairment experienced by these patients simply the consequence of the severity of their medical conditions? Third, what percent of these patients present with depressive symptoms only, anxious symptoms only, and a mixture of both? Fourth, how should the operational criteria for the syndrome(s) presented by these patients be defined? Method: A total of 666 patients from five primary care medical sites and two outpatient mental health sites were administered a semistructured psychiatric interview. Results: Patients presenting with affective symptoms that did not meet definitional thresholds for DSM-III-R axis I disorders were at least as common as patients with several of the already established anxiety and mood disorders in each of the seven sites, and their disorders were associated with significant distress or impairment. A nonspecific pattern of anxious and depressed symptoms was the modal presentation among these patients with currently subdefinitional threshold disorders, and they could be significantly differentiated in terms of current symptoms from patients presenting with a principal diagnosis of generalized anxiety disorder, major depressive episode, or panic disorder with agoraphobia. Conclusions: The authors recommend that a mixed anxiety- depression category be included in the DSM-IV appendix for proposed diagnostic categories that need further study. A criteria set is proposed.

Original languageEnglish (US)
Pages (from-to)1153-1162
Number of pages10
JournalAmerican Journal of Psychiatry
Issue number8
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'The DSM-IV field trial for mixed anxiety-depression'. Together they form a unique fingerprint.

Cite this