Abstract
Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen family, can be expressed as a membrane-associated protein with coagulation activity or in a secreted form possessing unique immune suppressive functions. The biological importance of Fgl2 is evident within viral-induced fibrin depositing inflammatory diseases and malignancies and provides a compelling rationale for Fgl2 expression to not only be considered as a disease biomarker but also as a therapeutic target. This article will provide a comprehensive review of the currently known biological properties of Fgl2 and clarifies future scientific directives.
Original language | English (US) |
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Pages (from-to) | 325-339 |
Number of pages | 15 |
Journal | International Reviews of Immunology |
Volume | 35 |
Issue number | 4 |
DOIs | |
State | Published - Jul 3 2016 |
Externally published | Yes |
Keywords
- DC maturation
- Tregs
- fibrin deposit
- glioblastoma
- immune suppression
- inflammatory diseases
- liver injury
- membrane-bound procoagulant
- secreted immune checkpoint regulator
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology