Abstract
Glioblastomas (GBMs) are complex ecosystems composed of highly multifaceted tumor and myeloid cells capable of responding to different environmental pressures, including therapies. Recent studies have uncovered the diverse phenotypical identities of brain-populating myeloid cells. Differences in the immune proportions and phenotypes within tumors seem to be dictated by molecular features of glioma cells. Furthermore, increasing evidence underscores the significance of interactions between myeloid cells and glioma cells that allow them to evolve in a synergistic fashion to sustain tumor growth. In this review, we revisit the current understanding of glioma-infiltrating myeloid cells and their dialogue with tumor cells in consideration of their increasing recognition in response and resistance to immunotherapies as well as the immune impact of the current chemoradiotherapy used to treat gliomas.
| Original language | English (US) |
|---|---|
| Article number | 13382 |
| Journal | International journal of molecular sciences |
| Volume | 22 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 1 2021 |
Funding
Funding: This work was supported by the National Institute of Health R01 CA120813, NS120547, and R01 NS110703-01A1. V.A.A. is supported by the Mexican government through the Mexican National Council for Science and Technology and the Plan of Combined Studies in Medicine of the National Autonomous University of Mexico.
Keywords
- Gliomas
- Immunotherapy
- Macrophages
- Microglia
ASJC Scopus subject areas
- Molecular Biology
- Spectroscopy
- Catalysis
- Inorganic Chemistry
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry