TY - JOUR
T1 - The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
AU - de Azevedo, Vera Lucia Fernandes
AU - Santos, Paulo Sergio Santana
AU - De Oliveira Jr, Gildasio S
AU - Módolo, Gabriel Pinheiro
AU - Domingues, Maria Aparecida Custódio
AU - Castiglia, Yara Marcondes Machado
AU - Vianna, Pedro Thadeu Galvão
AU - Vane, Luiz Antonio
AU - Módolo, Norma Sueli Pinheiro
PY - 2013/1/1
Y1 - 2013/1/1
N2 - PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1 or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
AB - PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1 or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
KW - Acute kidney injury
KW - Colloids
KW - Fluid therapy
KW - Hetastarch
KW - Rats
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M3 - Article
C2 - 23338107
AN - SCOPUS:84872905611
SN - 0102-8650
VL - 28
SP - 5
EP - 9
JO - Acta Cirurgica Brasileira
JF - Acta Cirurgica Brasileira
IS - 1
ER -