The effect of arachidonic acid on airway responses of rhesus monkeys

Roy Patterson*, Kathleen E. Harris, Paul A. Greenberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Rhesus monkeys with immediate-type airway responses to ascaris antigen were used to study the effect of arachidonic acid (Ar). Arachidonic acid produced no changes in pulmonary function parameters when delivered by aerosol at varying doses. However, when Ar was aerosolized prior to aerosol antigen challenge this resulted in a selective increase in pulmonary resistance (PR). This effect in PR was variable with intravenous Ar. Indomethacin (I) by aerosol was evaluated to determine whether it would block the post Ar increase in PR. This could not be accomplished because both aerosolized and intravenous I had a similar effect on the PR following antigen challenge. These effects of Ar and I may be due to production of airway reactive prostaglandins, their precursers or substances such as slow reacting substance.

Original languageEnglish (US)
Pages (from-to)389-399
Number of pages11
JournalLife Sciences
Volume22
Issue number5
DOIs
StatePublished - Feb 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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