The effect of A1015 on DNA synthesis of D-galactosamine damaged mice hepatotoxicity

Bi Chong Liu; Wen An Qiang; Yu Seng Wang

The effect of A₁₀₁₅ on DNA synthesis of D-galactosamine damaged mice hepatotoxicity

Bi Chong Liu^*, Wen An Qiang, Yu Seng Wang

^*Corresponding author for this work

CLP - Chemistry of Life Processes Institute

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To study the effect of A₁₀₁₅ on D-galactosamine induced mice hepatotoxicity. METHODS: The effect of three doses of A₁₀₁₅ on DNA biosynthesis of D-galactosamine-induced mice hepatotoxicity were tested. The time curve of A₁₀₁₅ on DNA synthesis of D-GL induced mice hepatotoxicity was also observed. RESULTS: The experiments demonstrated that 2.5 mg·kg^-1 is the optimum dose for A₁₀₁₅ to show liver-protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D-GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A₁₀₁₅ group. Thus both HGF and A₁₀₁₅ showed anti-hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION: A₁₀₁₅ may reduce liver necrosis induced by D-galactosamine and promote the DNA synthesis of mice liver cells.

Original language	English (US)
Pages (from-to)	441-443
Number of pages	3
Journal	Chinese Pharmacological Bulletin
Volume	18
Issue number	4
State	Published - Jan 1 2002

Keywords

H-TdR uptakes
A
Aristolochia tuberosa CF Liang et SM huang
CPM,DPM
D-galactosamine (D-G1)
DNA
HGF

ASJC Scopus subject areas

Pharmacology

Cite this

@article{b6df722d92504fb5ad6067169a006901,

title = "The effect of A1015 on DNA synthesis of D-galactosamine damaged mice hepatotoxicity",

abstract = "AIM: To study the effect of A1015 on D-galactosamine induced mice hepatotoxicity. METHODS: The effect of three doses of A1015 on DNA biosynthesis of D-galactosamine-induced mice hepatotoxicity were tested. The time curve of A1015 on DNA synthesis of D-GL induced mice hepatotoxicity was also observed. RESULTS: The experiments demonstrated that 2.5 mg·kg-1 is the optimum dose for A1015 to show liver-protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D-GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A1015 group. Thus both HGF and A1015 showed anti-hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION: A1015 may reduce liver necrosis induced by D-galactosamine and promote the DNA synthesis of mice liver cells.",

keywords = "H-TdR uptakes, A, Aristolochia tuberosa CF Liang et SM huang, CPM,DPM, D-galactosamine (D-G1), DNA, HGF",

author = "Liu, {Bi Chong} and Qiang, {Wen An} and Wang, {Yu Seng}",

year = "2002",

month = jan,

day = "1",

language = "English (US)",

volume = "18",

pages = "441--443",

journal = "Chinese Pharmacological Bulletin",

issn = "1001-1978",

publisher = "Institute of Clinical Pharmacology",

number = "4",

}

TY - JOUR

T1 - The effect of A1015 on DNA synthesis of D-galactosamine damaged mice hepatotoxicity

AU - Liu, Bi Chong

AU - Qiang, Wen An

AU - Wang, Yu Seng

PY - 2002/1/1

Y1 - 2002/1/1

N2 - AIM: To study the effect of A1015 on D-galactosamine induced mice hepatotoxicity. METHODS: The effect of three doses of A1015 on DNA biosynthesis of D-galactosamine-induced mice hepatotoxicity were tested. The time curve of A1015 on DNA synthesis of D-GL induced mice hepatotoxicity was also observed. RESULTS: The experiments demonstrated that 2.5 mg·kg-1 is the optimum dose for A1015 to show liver-protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D-GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A1015 group. Thus both HGF and A1015 showed anti-hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION: A1015 may reduce liver necrosis induced by D-galactosamine and promote the DNA synthesis of mice liver cells.

AB - AIM: To study the effect of A1015 on D-galactosamine induced mice hepatotoxicity. METHODS: The effect of three doses of A1015 on DNA biosynthesis of D-galactosamine-induced mice hepatotoxicity were tested. The time curve of A1015 on DNA synthesis of D-GL induced mice hepatotoxicity was also observed. RESULTS: The experiments demonstrated that 2.5 mg·kg-1 is the optimum dose for A1015 to show liver-protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D-GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A1015 group. Thus both HGF and A1015 showed anti-hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION: A1015 may reduce liver necrosis induced by D-galactosamine and promote the DNA synthesis of mice liver cells.

KW - H-TdR uptakes

KW - A

KW - Aristolochia tuberosa CF Liang et SM huang

KW - CPM,DPM

KW - D-galactosamine (D-G1)

KW - DNA

KW - HGF

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M3 - Article

AN - SCOPUS:0036671984

SN - 1001-1978

VL - 18

SP - 441

EP - 443

JO - Chinese Pharmacological Bulletin

JF - Chinese Pharmacological Bulletin

IS - 4

ER -

The effect of A₁₀₁₅ on DNA synthesis of D-galactosamine damaged mice hepatotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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