The effect of A1015 on DNA synthesis of D-galactosamine damaged mice hepatotoxicity

Bi Chong Liu*, Wen An Qiang, Yu Seng Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To study the effect of A1015 on D-galactosamine induced mice hepatotoxicity. METHODS: The effect of three doses of A1015 on DNA biosynthesis of D-galactosamine-induced mice hepatotoxicity were tested. The time curve of A1015 on DNA synthesis of D-GL induced mice hepatotoxicity was also observed. RESULTS: The experiments demonstrated that 2.5 mg·kg-1 is the optimum dose for A1015 to show liver-protective activity. The results suggested that HGF can not only offset the hepatotoxicity induced by D-GL, but also promote the DNA synthesis of mice liver cells. And the highest DPM value for HGF group is higher than that of A1015 group. Thus both HGF and A1015 showed anti-hepatotoxic activity and promoting activity on mice liver cell DNA synthesis. CONCLUSION: A1015 may reduce liver necrosis induced by D-galactosamine and promote the DNA synthesis of mice liver cells.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalChinese Pharmacological Bulletin
Volume18
Issue number4
StatePublished - Jan 1 2002

Keywords

  • H-TdR uptakes
  • A
  • Aristolochia tuberosa CF Liang et SM huang
  • CPM,DPM
  • D-galactosamine (D-G1)
  • DNA
  • HGF

ASJC Scopus subject areas

  • Pharmacology

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