Messung des Calcium-Einflusses auf die Strom-Spannungsbeziehung der erregbaren Membran am Ranvier-Knoten

Günter Albrecht-Bühler

doi:10.1007/BF00380845

Messung des Calcium-Einflusses auf die Strom-Spannungsbeziehung der erregbaren Membran am Ranvier-Knoten

Translated title of the contribution: The effect of calcium on the current-voltage-relation of the excitable membrane at the Ranvier-node

Günter Albrecht-Bühler^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

An increase of the extracellular calcium-concentration shifts the extreme current values of the current-voltage-relation of a Ranvier-node towards depolarization. This influence can be described by the change of one single parameter V_Tγ of an equation representing the current-voltage-characteristic. V_Tγ referres to the potential at which the s-shaped step-function of resistance change assumes the arithmetical mean of its limiting values. The step-function compares to the variable of potassium conductance n_∞⁴(V). An increase of [Ca^··]_a shifts V_Tγ towards depolarizing potentials. V_Tγ is also found to depend on [K^·]_a. The influence of calcium on membrane potential is interpreted as a consequence of the observed shift of V_Tγ.

Translated title of the contribution	The effect of calcium on the current-voltage-relation of the excitable membrane at the Ranvier-node
Original language	German
Pages (from-to)	23-34
Number of pages	12
Journal	Pflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere
Volume	300
Issue number	1
DOIs	https://doi.org/10.1007/BF00380845
State	Published - Mar 1 1968

Keywords

Calcium
Electro-Physiology
Ranvier-Node
Stationary Current-Voltage Relation

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

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title = "Messung des Calcium-Einflusses auf die Strom-Spannungsbeziehung der erregbaren Membran am Ranvier-Knoten",

abstract = "An increase of the extracellular calcium-concentration shifts the extreme current values of the current-voltage-relation of a Ranvier-node towards depolarization. This influence can be described by the change of one single parameter VTγ of an equation representing the current-voltage-characteristic. VTγ referres to the potential at which the s-shaped step-function of resistance change assumes the arithmetical mean of its limiting values. The step-function compares to the variable of potassium conductance n∞4(V). An increase of [Ca··]a shifts VTγ towards depolarizing potentials. VTγ is also found to depend on [K·]a. The influence of calcium on membrane potential is interpreted as a consequence of the observed shift of VTγ.",

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N2 - An increase of the extracellular calcium-concentration shifts the extreme current values of the current-voltage-relation of a Ranvier-node towards depolarization. This influence can be described by the change of one single parameter VTγ of an equation representing the current-voltage-characteristic. VTγ referres to the potential at which the s-shaped step-function of resistance change assumes the arithmetical mean of its limiting values. The step-function compares to the variable of potassium conductance n∞4(V). An increase of [Ca··]a shifts VTγ towards depolarizing potentials. VTγ is also found to depend on [K·]a. The influence of calcium on membrane potential is interpreted as a consequence of the observed shift of VTγ.

AB - An increase of the extracellular calcium-concentration shifts the extreme current values of the current-voltage-relation of a Ranvier-node towards depolarization. This influence can be described by the change of one single parameter VTγ of an equation representing the current-voltage-characteristic. VTγ referres to the potential at which the s-shaped step-function of resistance change assumes the arithmetical mean of its limiting values. The step-function compares to the variable of potassium conductance n∞4(V). An increase of [Ca··]a shifts VTγ towards depolarizing potentials. VTγ is also found to depend on [K·]a. The influence of calcium on membrane potential is interpreted as a consequence of the observed shift of VTγ.

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KW - Electro-Physiology

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KW - Stationary Current-Voltage Relation

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Messung des Calcium-Einflusses auf die Strom-Spannungsbeziehung der erregbaren Membran am Ranvier-Knoten

Abstract

Keywords

ASJC Scopus subject areas

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