Abstract
The effect of acute coronary ligation on infarct size was studied in (1) ten acute control dogs, which were non-denervated, (2) in six acutely denervated dogs in which the heart was denervated immediately prior to coronary ligation and in which intra-cardiac reflexes were pharmacologically blocked, (3) in seven chronically denervated dogs in which intrapericardial nerves were cut 2 weeks prior to ligation, and (4) in four dogs which were sham-operated 2 weeks prior to ligation. Infarct size was determined using a nitro blue tetrazolium stain for dehydrogenase activity. Infarct sizes in acute controls, acutely denervated, chronically denervated, and sham-operated hearts were 20.1, 15.0, 3.8, and 21.0 percent of left ventricular weight, respectively. Infarct sizes in acutely and chronically denervated hearts were significantly less than in acute controls (P < 0.05). In further studies the fluorescent stain thioflavin S was used to demonstrate that perfusion of myocardium distal to the ligation was substantially greater in chronically denervated hearts than in acute controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 738-746 |
| Number of pages | 9 |
| Journal | American heart journal |
| Volume | 95 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1978 |
Funding
From the Department of Medical Physiology, Texas A t M University, College of Medicine, College Station, Texas. This research was supported by National Institutes of Health grant ROl-HL20286 and by a grant from the Texas Affiliate of the American Heart Association. Received for publication Sept. 27, 1977. Accepted for publication Nov. 7, 1977. Reprint requests: Carl E. Jones, Ph.D., Dept. of Medical Physiology, Texas A & M University College of Medicine, Olin E. Teague Research Center, College Station, Texas 77843. *Fellow of Chicago Heart Association, Department of Physiology, Loyola University, Stritch School of Medicine, Maywood, Ill.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine