Abstract
The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 371-374 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 176 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 13 1990 |
Funding
The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MOlRR00080 and grants from the Laureate Foundation (NARSAD) and Sawyer Foundations. H.Y.M. is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Mr. Matthew A. Schreiber for technical assistance and to Ms. Lee Mason for typing the manuscript.
Keywords
- Clozapine (chronic)
- Dopamine release and metabolism
- Haloperidol (chronic)
- Microdialysis
ASJC Scopus subject areas
- Pharmacology