The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

Junji Ichikawa; Herbert Y. Meltzer

doi:10.1016/0014-2999(90)90033-3

The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

Junji Ichikawa^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.

Original language	English (US)
Pages (from-to)	371-374
Number of pages	4
Journal	European Journal of Pharmacology
Volume	176
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(90)90033-3
State	Published - Feb 13 1990

Keywords

Clozapine (chronic)
Dopamine release and metabolism
Haloperidol (chronic)
Microdialysis

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(90)90033-3

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title = "The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis",

abstract = "The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.",

keywords = "Clozapine (chronic), Dopamine release and metabolism, Haloperidol (chronic), Microdialysis",

author = "Junji Ichikawa and Meltzer, {Herbert Y.}",

note = "Funding Information: The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MOlRR00080 and grants from the Laureate Foundation (NARSAD) and Sawyer Foundations. H.Y.M. is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Mr. Matthew A. Schreiber for technical assistance and to Ms. Lee Mason for typing the manuscript.",

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T1 - The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

AU - Ichikawa, Junji

AU - Meltzer, Herbert Y.

N1 - Funding Information: The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MOlRR00080 and grants from the Laureate Foundation (NARSAD) and Sawyer Foundations. H.Y.M. is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Mr. Matthew A. Schreiber for technical assistance and to Ms. Lee Mason for typing the manuscript.

PY - 1990/2/13

Y1 - 1990/2/13

N2 - The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.

AB - The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.

KW - Clozapine (chronic)

KW - Dopamine release and metabolism

KW - Haloperidol (chronic)

KW - Microdialysis

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VL - 176

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EP - 374

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

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The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

Abstract

Keywords

ASJC Scopus subject areas

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