The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

Junji Ichikawa*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalEuropean Journal of Pharmacology
Volume176
Issue number3
DOIs
StatePublished - Feb 13 1990

Keywords

  • Clozapine (chronic)
  • Dopamine release and metabolism
  • Haloperidol (chronic)
  • Microdialysis

ASJC Scopus subject areas

  • Pharmacology

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