The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis

Baoling Chai, Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalNeuroscience Letters
Volume140
Issue number1
DOIs
StatePublished - Jun 8 1992

Keywords

  • Apomorphine
  • Clozapine
  • Dopamine
  • Microdialysis
  • Nucleus accumbens
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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