The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis

Baoling Chai; Herbert Y. Meltzer

doi:10.1016/0304-3940(92)90678-Z

The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis

Baoling Chai, Herbert Y. Meltzer^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Neuroscience Letters
Volume	140
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(92)90678-Z
State	Published - Jun 8 1992

Keywords

Apomorphine
Clozapine
Dopamine
Microdialysis
Nucleus accumbens
Striatum

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(92)90678-Z

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title = "The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis",

abstract = "Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.",

keywords = "Apomorphine, Clozapine, Dopamine, Microdialysis, Nucleus accumbens, Striatum",

author = "Baoling Chai and Meltzer, {Herbert Y.}",

note = "Funding Information: The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MO1RR00080, the Department of Veterans Affairs and grants from the Cleveland, John Pascal Sawyer and Elisabeth Severance Prentiss Foundations. H.Y.M, is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Ms. Elisa K. Caraulia for technical assistance. The secretarial assistance of Ms. Lee Mason is greatly appreciated.",

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doi = "10.1016/0304-3940(92)90678-Z",

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AU - Chai, Baoling

AU - Meltzer, Herbert Y.

N1 - Funding Information: The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MO1RR00080, the Department of Veterans Affairs and grants from the Cleveland, John Pascal Sawyer and Elisabeth Severance Prentiss Foundations. H.Y.M, is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Ms. Elisa K. Caraulia for technical assistance. The secretarial assistance of Ms. Lee Mason is greatly appreciated.

PY - 1992/6/8

Y1 - 1992/6/8

N2 - Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.

AB - Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.

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KW - Dopamine

KW - Microdialysis

KW - Nucleus accumbens

KW - Striatum

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The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis

Abstract

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