Abstract
Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 μ/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 47-50 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 140 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 8 1992 |
Funding
The research reported was supported in part by USPHS MH 41684, MH 41594, GCRC MO1RR00080, the Department of Veterans Affairs and grants from the Cleveland, John Pascal Sawyer and Elisabeth Severance Prentiss Foundations. H.Y.M, is the recipient of a USPHS Research Career Scientist Award MH 47808. We are grateful to Ms. Elisa K. Caraulia for technical assistance. The secretarial assistance of Ms. Lee Mason is greatly appreciated.
Keywords
- Apomorphine
- Clozapine
- Dopamine
- Microdialysis
- Nucleus accumbens
- Striatum
ASJC Scopus subject areas
- General Neuroscience