Abstract
Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in coordinating a set of diverse brain functions. Given the few human studies investigating this claim, we decided to study the effects of claustrum lesions on consciousness in 171 combat veterans with penetrating traumatic brain injuries. Additionally, we studied the effects of claustrum lesions and loss of consciousness on long-term cognitive abilities. Claustrum damage was associated with the duration, but not frequency, of loss of consciousness, indicating that the claustrum may have an important role in regaining, but not maintaining, consciousness. Total brain volume loss, but not claustrum lesions, was associated with long-term recovery of neurobehavioral functions. Our findings constrain the current understanding of the neurobehavioral functions of the claustrum and its role in maintaining and regaining consciousness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 256-264 |
| Number of pages | 9 |
| Journal | Consciousness and Cognition |
| Volume | 36 |
| DOIs | |
| State | Published - Nov 1 2015 |
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Keywords
- Claustrum
- Consciousness
- Neurobehavioral function
- Penetrating traumatic brain injury
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Developmental and Educational Psychology
Cite this
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The effect of claustrum lesions on human consciousness and recovery of function. / Chau, Aileen; Salazar, Andres M.; Krueger, Frank; Cristofori, Irene; Grafman, Jordan Henry.
In: Consciousness and Cognition, Vol. 36, 01.11.2015, p. 256-264.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effect of claustrum lesions on human consciousness and recovery of function
AU - Chau, Aileen
AU - Salazar, Andres M.
AU - Krueger, Frank
AU - Cristofori, Irene
AU - Grafman, Jordan Henry
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in coordinating a set of diverse brain functions. Given the few human studies investigating this claim, we decided to study the effects of claustrum lesions on consciousness in 171 combat veterans with penetrating traumatic brain injuries. Additionally, we studied the effects of claustrum lesions and loss of consciousness on long-term cognitive abilities. Claustrum damage was associated with the duration, but not frequency, of loss of consciousness, indicating that the claustrum may have an important role in regaining, but not maintaining, consciousness. Total brain volume loss, but not claustrum lesions, was associated with long-term recovery of neurobehavioral functions. Our findings constrain the current understanding of the neurobehavioral functions of the claustrum and its role in maintaining and regaining consciousness.
AB - Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in coordinating a set of diverse brain functions. Given the few human studies investigating this claim, we decided to study the effects of claustrum lesions on consciousness in 171 combat veterans with penetrating traumatic brain injuries. Additionally, we studied the effects of claustrum lesions and loss of consciousness on long-term cognitive abilities. Claustrum damage was associated with the duration, but not frequency, of loss of consciousness, indicating that the claustrum may have an important role in regaining, but not maintaining, consciousness. Total brain volume loss, but not claustrum lesions, was associated with long-term recovery of neurobehavioral functions. Our findings constrain the current understanding of the neurobehavioral functions of the claustrum and its role in maintaining and regaining consciousness.
KW - Claustrum
KW - Consciousness
KW - Neurobehavioral function
KW - Penetrating traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84936989072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84936989072&partnerID=8YFLogxK
U2 - 10.1016/j.concog.2015.06.017
DO - 10.1016/j.concog.2015.06.017
M3 - Article
C2 - 26186439
AN - SCOPUS:84936989072
VL - 36
SP - 256
EP - 264
JO - Consciousness and Cognition
JF - Consciousness and Cognition
SN - 1053-8100
ER -